To mark the reclassification of stroke as a neurological disease in the new International Classification of Disease, this collection brings you a selection of articles that address some of the latest and most exciting advances in stroke, including Reviews and commentaries written by world-leading stroke neurologists.

Much like our oceans, the world of clinical and biomedical research is vast, fast-paced, dynamic and full of unanswered questions. In 2017, numerous advances were made that could change the tide of efforts to fight disease. The Key Advances in Medicine eBook distils the major discoveries made in 2017 and highlights trends to look out for in 2018.

2017 marks the 200th anniversary since James Parkinson published his Essay on the Shaking Palsy. To mark this event, Nature Reviews bring together a collection of cutting edge articles that summarize the current basic and clinical research in Parkinson disease.

Beginning in the December 2016 issue, Nature Reviews Neurology will be publishing a series of articles looking at recent advances in our understanding of disease mechanisms, and in the diagnosis and management of a variety of peripheral neuropathies.

Collectively, rare diseases account for a substantial proportion of the worldwide burden of neurological disease, despite their individual low prevalence. The articles in this series highlight the challenges of studying and treating rare neurological diseases, emphasizing the importance of international and multidisciplinary collaboration to foster interactions between patients, clinicians, researchers and advocacy groups.

In November 2015, Nature Reviews Neurology(originally published asNature Clinical Practice Neurology) celebrates 10 years since the launch of the journal. To mark this occasion, we present an anniversary issue containing specially commissioned articles that highlight progress in neurology over the past decade and outline the research priorities for the next 10 years. A special infographic provides a snapshot of 10 years of the journal in numbers.

The past 10 years has seen great advances in the understanding and treatment of human disease. For expert perspectives on the most important breakthroughs, don't miss the FREE A Decade in Medicine eBook. In this special collection of 47 articles, leading experts highlight the most important advances in eight medical specialties between 2004 and 2015, and comment on future developments in their fields.

Beginning in the August 2015 issue, Nature Reviews Neurology will be publishing a series of articles that outline the most recent advances and challenges in prevention, diagnosis and management of infections of the CNS.

Treatment-resistant epilepsy remains a major burden at both global and individual levels. About 1% of individuals have epilepsy and, in over one-quarter of patients, antiseizure medications do not provide sufficient seizure control, which can result in dramatically impaired quality of life and increased mortality. In this special focus issue on epilepsy, cutting-edge investigators from around the world highlight the important challenges and progress in epilepsy research and clinical practice. The topics in this issue include global challenges in paediatric epilepsy, the genetic background of the epilepsies and its implications for genetic diagnosis and personalized medicine, prospects for gene therapy in epilepsy, brain stimulation in refractory epilepsy, and mechanisms of sudden unexpected death in epilepsy.

A web focus from Cell Death & Differentiation, Cell Death & Disease, Nature Reviews Cancer, Nature Cell Biology, Nature Reviews Molecular Cell Biology and Nature Structural & Molecular Biology. We hope you enjoy this focus including work from the world's most recognized experts in the field of autophagy.

With human life spans continuing to increase worldwide, the ability to keep brain functions intact into old age becomes ever more important. As the articles in this Clinical Collection illustrate, approaches to preventing or arresting neurodegeneration can take many forms, from lifestyle changes aimed at preserving the integrity of the brain, to pharmacological treatments and immunological interventions targeted at specific neurodegenerative disease mechanisms.

Chronic pain is estimated to affect over one-quarter of the world's population, and presents a considerable therapeutic challenge. This Nature Collection brings together articles from Nature,Nature Medicine,Nature Neuroscience,Nature Reviews NeurologyandNature Reviews Neurosciencethat highlight recent advances towards understanding the risk factors and mechanisms that underlie chronic pain, and developing effective, non-addictive treatments for this highly prevalent condition.