Research Highlights

Researchers in China and South Korea have developed a rapid immunodot assay to detect aquaporin 4-targeting IgG autoantibodies in the serum of individuals with neuromyelitis optica spectrum disorder.

New research in a mouse model of Parkinson disease indicates that the cholesterol metabolite 27-hydroxycholesterol drives α-synuclein pathology.

Blood biomarkers of Alzheimer disease are influenced by sex and medical comorbidities but not by race, according new research.

Two new studies have provided important mechanistic insights into TDP-43 pathology, a hallmark of neurodegenerative conditions such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

A new study identifies LONRF2 as a protein quality control ubiquitin ligase that is induced in senescent neurons and seems to protect them against degeneration

The 2023 Alzheimer’s Association International Conference (AAIC) was held in Amsterdam, Netherlands on the 16–20 July 2023.

Biomarkers for Alzheimer disease can be measured from finger-prick blood samples, according to new findings presented at AAIC 2023.

New findings announced at AAIC 2023 demonstrate the potential of CRISPR-based therapies for Alzheimer disease.

Gut microbiome changes are present in both preclinical Alzheimer disease and prodromal Parkinson disease, new research indicates.

Loss of myelin integrity, which occurs during ageing, promotes deposition of amyloid-β in the brain, according to new research.

Oligomeric tau accumulates in the synapses of people with Alzheimer disease, according to new research using post-mortem brain samples.

Researchers in China have developed a functional nucleic acid-based responsive artificial enzyme that enables continuous production of levodopa in a mouse model of Parkinson disease.

A new study indicates loss of hypothalamic melanin-concentrating hormone in ALS, providing insights into the mechanisms underlying weight loss in individuals with the disease.

An α-synuclein seed amplification assay can reliably identify people with Parkinson disease, even at the prodromal stage, new research indicates.

An approach that uses magnetic nanotubes and a rotating magnetic field to induce cell death shows promise in a mouse model of glioblastoma.

A new study provides mechanistic insights into the role of TDP43 in regulating the expression of stathmin 2 — a protein that is abundant in motor neurons and is required for axonal regeneration after injury.

According to new research in a mouse model, systemic immune exhaustion could underlie the association between obesity and risk of developing Alzheimer disease.

In a recent PET study, microglial activation in the frontal cortex predicted cognitive decline in individuals with frontotemporal dementia.

New findings suggest that bidirectional communication between T cells and the gut microbiome can influence autoimmune disease.