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  • Findings of phase III trials of the Bruton’s tyrosine kinase inhibitor evobrutinib in patients with relapsing multiple sclerosis were recently presented at the ACTRIMS Forum.

    • Heather Wood
    Research Highlight
  • New data recently reported at the ACTRIMS Forum add to growing evidence of an aetiological role for Epstein–Barr virus infection in multiple sclerosis.

    • Heather Wood
    Research Highlight
  • A computational neuroimaging study has shed new light on the relationship between morphological changes in the brain in schizophrenia and the network architecture of the brain, providing evidence to support two network theories of the disorder.

    • Martijn P. van den Heuvel
    • Sara L. Seoane
    News & Views
  • This month, Nature Reviews Neurology launches a Series to highlight the importance of diversity, equity and inclusion in the neurology community and in neurological care to address health disparities and thereby to improve global brain health.

  • Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a broad spectrum of diversity, equity and inclusion initiatives. We spoke with stroke neurologist Nirali Vora from the USA about her work to build neurology capacity in low and middle-income countries.

    • Lisa Kiani
  • The recent approval of omaveloxolone for the treatment of Friedreich ataxia in the USA and Europe represents an important milestone in the field of rare neurological diseases. However, many challenges lie ahead, including the translation of trial results into clinical practice, and the management of patients’ expectations.

    • Sylvia Boesch
    • Elisabetta Indelicato
  • Various neurostimulation techniques are being explored for the treatment of physical impairments in people with stroke. This Review summarizes our current knowledge of the techniques that are now in clinical use or have reached the stage of pivotal trials alongside emerging techniques and highlights the need for further studies.

    • Jesse Dawson
    • Azmil H. Abdul-Rahim
    • Teresa J. Kimberley
    Review Article
  • Post-traumatic epilepsy is a major driver of disability associated with traumatic brain injury. This article reviews the epidemiology and clinical features of post-traumatic epilepsy and discusses how an understanding of the underlying epileptogenic mechanisms might inform the development of anti-epileptogenic medications.

    • Matthew Pease
    • Kunal Gupta
    • James F. Castellano
    Review Article
  • In this Review, the authors discuss the unique neurological health disparities faced by sexual and gender minority (LGBT+) people. The Review presents clinical considerations alongside language and practice recommendations to promote inclusive care, and highlights the gaps in need of further research.

    • Salvatore Giovanni Volpe
    • Joya Ahmad
    • Nicole Rosendale
    Review Article
  • Since its instigation in cancer research in the 1930s, the disease-staging concept has become a crucial tool in clinical research and medical practice. Two new papers have proposed biological staging and classification systems based on α-synuclein pathology for Parkinson disease and related conditions.

    • Nobutaka Hattori
    News & Views
  • A new study has found evidence of α-synuclein aggregates — a key pathological hallmark of Parkinson disease — in the gut and brain in people and animals with inflammatory bowel disease.

    • Heather Wood
    Research Highlight
  • Recent clinical trials have highlighted the need for Alzheimer disease (AD) staging rather than simply noting the presence or absence of AD pathology. This article reviews current biomarker-based AD staging systems and outlines hypothetical frameworks to stage AD severity using fluid biomarkers.

    • Joseph Therriault
    • Suzanne E. Schindler
    • Pedro Rosa-Neto
    Review Article
  • Alzheimer disease is a complex and multifactorial condition. The authors of this Perspective suggest that its lack of a singular common pathogenesis prevents it from being regarded as a straightforward ‘disease’ and that treatment will therefore require a multifaceted approach.

    • Amos D. Korczyn
    • Lea T. Grinberg
  • In this Review, Hamilton dissects the importance of racial and ethnic diversity among the neurology workforce for providing inclusive and equitable care to diverse populations. The Review summarizes current barriers to achieving diversity in the field and presents strategic approaches to overcoming these.

    • Roy H. Hamilton
    Review Article
  • Success in a trial of low-intensity ultrasound combined with an amyloid-β antibody represents a major stride towards integrating pharmacological and nonpharmacological approaches to reduce the amyloid-β load in patients with mild Alzheimer disease. This trial also highlights the potential of therapeutic ultrasound modalities to combat neurodegenerative diseases.

    • Jürgen Götz
    • Pranesh Padmanabhan
    News & Views