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The ability to classify brain tumors on the basis of molecular data is expected to revolutionize the diagnosis and treatment of brain cancer. In this Viewpoint article, Mischel and Cloughesy discuss the current status of molecularly targeted therapies for brain tumors, and outline a 'roadmap' for future investigations.
Stroke and peripheral neuropathy are recognized neurological complications of diabetes, and epidemiological evidence is now emerging to implicate the prediabetic state of impaired glucose tolerance as a risk factor for these conditions. Singleton and Smith assess this evidence, and also consider the possibility of a link between impaired glucose tolerance and cognitive dysfunction.
Since its first appearance in the US in 1999, the arthropod-borne flavivirus West Nile virus has emerged as the main cause of epidemic meningoencephalitis in North America. DeBiasi and Tyler review the epidemiology, clinical features, diagnosis and prognosis of West Nile virus neuroinvasive disease, and discuss current treatments and prospects for future therapies.