Here, Timothy Steiner and Lars Stovner discuss the progression of migraine epidemiology over the last seven decades and question the apparent increase in migraine prevalence over time.

In this Perspective article, Lipkin et al. consider the contribution of cohort studies to our understanding of autism spectrum disorders (ASDs) and debate the promise and potential challenges of such studies for dissecting the causes of ASDs and developing interventional strategies.

Findings from a worldwide cohort of cognitively unimpaired individuals demonstrate that the presence of two canonical Alzheimer disease biomarkers — amyloid and tau — can reliably predict progression to mild cognitive impairment in the short-term. The results support the use of these biomarkers to diagnose preclinical Alzheimer disease in a clinical setting.

In a new study, targeted editing of the epigenome was found to reactivate silenced MECP2 in human embryonic stem cells, suggesting that a similar approach could be used to treat Rett syndrome in girls.

According to new research in a mouse model of frontotemporal dementia, hypoexcitability of the dorsomedial prefrontal cortex underlies lost empathy.

A genetic variant of the WNT receptor LRP6 exacerbates synapse degeneration in mouse models of ageing and Alzheimer’s disease, according to new research.

In a new study, targeted editing of the epigenome was found to reactivate silenced MECP2 in human embryonic stem cells, suggesting that a similar approach could be used to treat Rett syndrome in girls.

Normalizing aberrant calcium release from the endoplasmic reticulum restores lysosome function in AD models.

New findings suggest that neuroinflammation disrupts brain networks in Alzheimer disease independently of amyloid-β deposition.