Philip Patenall

Cerebral small vessel disease

From a focal to a global perspective

Latest Reviews

  • Review Article |

    In this Review, Ferretti et al. discuss the evidence for sex-related differences in Alzheimer disease symptoms, progression, risk factors and treatment, and consider how understanding sex differences is crucial in developing precision medicine.

    • Maria Teresa Ferretti
    • , Maria Florencia Iulita
    • , Enrica Cavedo
    • , Patrizia Andrea Chiesa
    • , Annemarie Schumacher Dimech
    • , Antonella Santuccione Chadha
    • , Francesca Baracchi
    • , Hélène Girouard
    • , Sabina Misoch
    • , Ezio Giacobini
    • , Herman Depypere
    •  & Harald Hampel
  • Review Article |

    Glioblastomas remain one of the most aggressive and lethal tumours, with no effective treatments available. Here, Xandra Breakefield and colleagues examine the ways in which glioblastomas manipulate brain cells and immune cells in their environment to support tumour growth and the opportunities available for new therapies that disrupt these interactions.

    • Marike L. Broekman
    • , Sybren L. N. Maas
    • , Erik R. Abels
    • , Thorsten R. Mempel
    • , Anna M. Krichevsky
    •  & Xandra O. Breakefield
  • Review Article |

    This Review appraises the available evidence for spatial navigation and/or orientation deficits in preclinical, prodromal and confirmed Alzheimer disease with a focus on using spatial navigation as a diagnostic tool. Research gaps and future research priorities are also identified.

    • Gillian Coughlan
    • , Jan Laczó
    • , Jakub Hort
    • , Anne-Marie Minihane
    •  & Michael Hornberger
  • Review Article |

    Non-rapid eye movement (NREM) sleep parasomnias are thought to derive from incomplete arousal from NREM sleep. Here, the authors present evidence for coexistence of sleep-like and wake-like brain activity in disorders of arousal, including confusional arousals, sleep terrors and sleepwalking.

    • Anna Castelnovo
    • , Régis Lopez
    • , Paola Proserpio
    • , Lino Nobili
    •  & Yves Dauvilliers
  • Perspective |

    New research is increasingly challenging old notions of an immunologically isolated CNS. In this Perspectives article, Jun Chen and colleagues highlight discoveries on the beneficial roles of regulatory immune cells in brain repair and regeneration, and discuss their promise as therapies for neurological disorders.

    • Xiaoming Hu
    • , Rehana K. Leak
    • , Angus W. Thomson
    • , Fang Yu
    • , Yuguo Xia
    • , Lawrence R. Wechsler
    •  & Jun Chen
  • Review Article |

    Free haemoglobin released from red blood cells after intracranial bleeding can lead to neurotoxicity and exacerbate injury. In this Review, the authors consider the biology behind haemoglobin toxicity and the clinical potential of targeting haemoglobin scavenging systems to aid recovery.

    • Diederik Bulters
    • , Ben Gaastra
    • , Ardalan Zolnourian
    • , Sheila Alexander
    • , Dianxu Ren
    • , Spiros L. Blackburn
    • , Mark Borsody
    • , Sylvain Doré
    • , James Galea
    • , Koji Iihara
    • , Paul Nyquist
    •  & Ian Galea

News & Comment

Collection

Stroke as a neurological disease

Philip Patenall

Stroke as a neurological disease

To mark the reclassification of stroke as a neurological disease in the new International Classification of Disease, this collection brings you a selection of articles that address some of the latest and most exciting advances in stroke, including Reviews and commentaries written by world-leading stroke neurologists.

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