Reviews on bariatric surgery, kidney stone disease and RCC immunology, a Consensus Statement on COVID-19 AKI, and commentaries on COVID-19 in nephrology and the timing of dialysis initiation in AKI.

A focus issue on precision medicine in nephrology, with Reviews on the genetics of complex kidney diseases, integration of multi-omics approaches, digital pathology and computational image analysis, and ontologies, a Viewpoint on the patients’ perspective, plus Commentaries on diagnoses of uncertain significance, ethics of genetic testing, gene–environment interactions and kidney tissue engineering.

A focus issue on innovations in dialysis, with Reviews on the current landscape of dialysis therapy and vascular access techniques plus commentaries on the patients’ perspective, regulatory considerations and innovative dialysis technologies. Also a Perspectives on ethical challenges in nephrology and commentaries on COVID-19 in nephrology and structural cells in organ immune responses.

Reviews on autophagy, purinergic signalling and plant-based diets to manage the risks and complications of CKD; plus commentaries on the impact of coronavirus in Brazil and cell therapy in transplantation.

Reviews on Genomic profiling in RCC and cognitive dysfunction in CKD; a Consensus guidelines for the management of hyperammonaemia in paediatric patients receiving CKRT; and commentaries on glomerular filtration mechanisms, renal effects of SGLT2 inhibitors and GLP1 agonists, nomenclature for kidney function and disease, and the mental health of health-care workers in the COVID-19 era.

Reviews on the genetics of diabetes mellitus and diabetes complications, dendritic cells and tools for the analysis of high-dimensional single-cell RNA sequencing data, plus commentaries on immunosuppression in COVID-19, eHealth in kidney care, PEXIVAS and suPAR in AKI.

Reviews on diabetic kidney disease, sensing of tubular flow and renal electrolyte transport and TonEBP as an immunometabolic stress protein plus commentaries on COVID-19, including controversies of RAS inhibition, risk among patients on dialysis and the rationale for extracorporeal therapies.

Reviews on green nephrology, targeting CKD progression, and angiogenesis and lymphangiogenesis in kidney disease plus commentaries on the obesity paradox in RCC and genetic studies of urinary metabolites.

Reviews on AKI outcomes, innate immunity in diabetic kidney disease, the epidemiology of hypertension and single-cell transcriptomic analyses of immune cells in lupus nephritis plus commentaries on the treatment of uraemic pruritus and the use of EHRs in clinical trials.

Reviews on AKI and hepatorenal syndrome in patients with cirrhosis, oncometabolites in renal cancer and clinical trial design plus commentaries on proteogenomic characterization of ccRCC and the link between pathogenic CUBN variants and proteinuria.

Reviews on iron, NAD+ homeostasis and use of single-cell technologies to map the immune system as well as Year in Review commentaries on single-cell technologies, development and regeneration, diabetic kidney disease, artificial intelligence and acute kidney injury in 2019.

Reviews on FGF23, sepsis and infection-associated glomerulonephritis, Perspectives on measured and estimated GFR, plus commentaries on type IV collagen and diabetic kidney disease and artificial intelligence in nephropathology.