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  • The DNA damage response is essential to genomic stability. Here, the authors discuss DNA damage-induced nephrotoxicity and kidney cancer, and the essential role of DNA repair in kidney homeostasis, as well as its potential to contribute to kidney dysfunction, including the links between DNA damage, cell-cycle control and ciliopathies.

    • Juan I. Garaycoechea
    • Catherine Quinlan
    • Martijn S. Luijsterburg
    Review Article
  • People with kidney disease are particularly vulnerable to the impacts of natural disasters and extreme weather events. As climate change is increasing the frequency and severity of these events, a robust response is needed to improve disaster preparedness and increase the resilience of these patients.

    • Amir Sapkota
    • Peter Kotanko
  • Thousands of environmental chemicals are used globally. However, despite clear evidence of their adverse effects on the kidney, substantial knowledge gaps remain. Further studies are needed to better understand the effects of chemical mixtures, windows of physiological susceptibility, vulnerable populations, and the intersection of chemical exposure with health risks associated with climate change and heat stress.

    • Alison P. Sanders
    • Nishad Jayasundara
  • Climate change is increasing global temperatures and causing more frequent and severe extreme heat events. The resulting additional disease burden is inequitably distributed. Strategies that reduce inequities in heat exposure and vulnerability to heat-related illness, as well as health protections at multiple levels (from individual to regional), are urgently needed to contain the looming crisis.

    • Jeremy Hess
  • An estimated 10–15% of individuals with hypertension are resistant to available antihypertensive therapies. Findings from two new clinical trials — BrigHTN and PRECISION — that assessed the blood pressure-lowering effects of the aldosterone synthase inhibitor baxdrostat and the dual endothelin receptor antagonist aprocitentan, respectively, suggest these approaches hold promise for patients with treatment-resistant hypertension.

    • R. M. Touyz
    • D. G. Harrison
    News & Views
  • Adequate nutrition is essential for kidney health; however, attempts to improve nutrition and food security have been hindered in recent years by man-made and natural disasters. Approaches to eradicate famine, improve nutritional status and reduce food insecurity are needed to reduce inequities and maintain kidney health in the face of adverse circumstances.

    • Gerjan Navis
  • The COVID-19 pandemic exposed flaws in the ability of the nephrology community to efficiently inform clinical decision making. To improve preparedness for the next pandemic, the nephrology community must work more closely together to ensure that research efforts are aligned and put in place a strategy for the effective dissemination of high-quality evidence in real-time.

    • Priya Vart
    • Luuk B. Hilbrands
    • Ron T. Gansevoort
  • This Review discusses the potential mechanisms by which regular exercise has beneficial effects on chronic inflammation, cardiovascular health, lipid metabolism, insulin resistance, sarcopenia and bone health in people with kidney disease. The authors highlight areas for further investigation to enhance the benefits of exercise for this population.

    • Nicolette C. Bishop
    • James O. Burton
    • Emma L. Watson
    Review Article
  • Any processes that impair kidney development in the developing fetus can have lifelong adverse consequences for renal health. Here, the authors discuss the effects of preterm birth and/or intrauterine growth restriction on kidney development and the impact of these exposures on the later development of chronic kidney disease.

    • Megan R. Sutherland
    • Mary Jane Black
    Review Article
  • Immune dysregulation contributes to the pathogenesis of preeclampsia. Here, the authors examine the role of immune cells and mediators in driving the oxidative stress and endothelial dysfunction that characterize this hypertensive disorder of pregnancy.

    • Evangeline Deer
    • Owen Herrock
    • Babbette LaMarca
    Review Article
  • The gut microbiota is increasingly recognized as an important factor in human health and disease. Here, the authors focus on the role of the gut microbiome in blood pressure regulation and discuss its clinical implications, as well as the challenges and potential of microbiome research.

    • Joanne A. O’Donnell
    • Tenghao Zheng
    • Francine Z. Marques
    Review Article
  • In this Review, the authors discuss the mineral-related factors and kidney-derived molecules that regulate osteocyte FGF23 production in health and disease. They also highlight potential approaches to the treatment of FGF23-related disorders of mineral metabolism that target key bone–kidney interactions.

    • Rafiou Agoro
    • Kenneth E. White
    Review Article
  • Primary hyperoxaluria is an inherited disorder that results from the overproduction of endogenous oxalate, leading to recurrent kidney stones, nephrocalcinosis, kidney failure and life-threatening systemic disease. This Consensus Statement from ERKNet and OxalEurope provides recommendations for the management of primary hyperoxaluria, including consideration of conventional therapies, new therapies and recommendations for patient follow-up.

    • Jaap W. Groothoff
    • Ella Metry
    • Justine Bacchetta
    Consensus Statement
  • Necroptosis is a form of necrotic cell death that leads to cell lysis and an inflammatory response in neighbouring tissues. This Review describes the molecular mechanisms that regulate the induction of necroptosis and current evidence implicating a role for necroptosis in the pathogenesis of kidney diseases.

    • Benedikt Kolbrink
    • Friedrich A. von Samson-Himmelstjerna
    • Stefan Krautwald
    Review Article
  • Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Here, the authors provide an overview of the basic biology of gasdermins and pyroptosis with a focus on the mechanisms by which these proteins may contribute to kidney disease.

    • Esteban E. Elias
    • Brayden Lyons
    • Daniel A. Muruve
    Review Article
  • More than three-quarters of cases of chronic kidney disease are caused by glomerular diseases with glomerulosclerosis, including diabetic kidney disease, hypertensive nephropathy and glomerulonephritis. Studies in 2022 provided insights into the molecular mechanisms that maintain dynamic glomerular structures and the responses of specific glomerular cell types during glomerular disease.

    • Emelie Lassén
    • Ilse S. Daehn
    Year in Review