Conflict zones hospital

Continuing kidney care in conflicts

  • Raymond Vanholder
  • Anja De Weggheleire
  • Rukshana Shroff
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  • SARS-CoV-2 and the kidney

    This article series aims to highlight basic, clinical and psychological aspects of COVID-19 in nephrology as well as the impact of the pandemic on research and clinical trials.

  • Tools & technologies in nephrology

    A series of articles that aim to explore the tools and techniques that are improving our understanding of renal development, physiology and disease mechanisms as well as contributing to advances in the screening, diagnosis and management of kidney diseases.

  • Humanitarian crises in nephrology

    A series of articles focusing on global humanitarian challenges in nephrology that contribute to widespread disparities in kidney health, including issues related to social injustices and environmental protection.

  • Genetics kidney

    This series of articles aims to explore all aspects of nephrogenetics, from the genetics of monogenic diseases to complex traits and the interpretation and application of genetic and genomic data to improve patient outcomes

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    • Chronic kidney disease (CKD) is often well advanced before it is detected. Although polygenic scores may enable the early stratification of patients at risk of CKD, the transferability of polygenic scores for the prediction of CKD to populations of non-European ancestry was limited. A new cross-ancestry polygenic score for CKD overcomes these issues, demonstrating good performance across ancestries.

      • Inga Steinbrenner
      • Anna Köttgen
      News & Views
    • Cellular senescence has beneficial functions in embryonic development, wound healing and tumour suppression but can also be maladaptive, contributing to cancer development and disease. This Review describes the mechanisms, hallmarks and consequences of senescence, as well as the therapeutic potential of senescence-targeting interventions.

      • Weijun Huang
      • LaTonya J. Hickson
      • Lilach O. Lerman
      Review Article
    • Two recent randomized trials provide evidence to guide the management of sepsis. The CLASSIC trial reports that restrictive fluid therapy has no mortality benefit compared to a standard regimen in patients with septic shock, whereas the LOVIT trial reports that high-dose intravenous vitamin C might be harmful in patients with severe sepsis.

      • Mark Philip Plummer
      • Rinaldo Bellomo
      News & Views
    • Necroptosis is a form of regulated necrosis in which RIPK3 is activated by binding to RIP homotypic interaction motif (RHIM)-containing proteins. Now, researchers describe a non-canonical pathway of RIPK3 activation that is triggered by osmotic stress and NHE1-mediated cytosol alkalinization. This previously undescribed mechanism of osmotic stress-induced necroptosis might have implications for treating cancer and other diseases.

      • Alberto Ortiz
      • Ana B. Sanz
      News & Views
    • Alloimmune T cell responses have a crucial role in graft rejection. Here, the authors examine the factors that regulate T cell activation, differentiation and function in secondary lymphoid organs and in the graft, including the different pathways of allorecognition, innate–adaptive immunity crosstalk and the role of survival cytokines.

      • Charlotte Duneton
      • Pamela D. Winterberg
      • Mandy L. Ford
      Review Article

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