Pig genetics

Progress in xenotransplantation: overcoming immune barriers

  • Megan Sykes
  • David H. Sachs
Review Article

Announcements

  • SARS-CoV-2 and the kidney

    This article series aims to highlight basic, clinical and psychological aspects of COVID-19 in nephrology as well as the impact of the pandemic on research and clinical trials.

  • Tools & technologies in nephrology

    A series of articles that aim to explore the tools and techniques that are improving our understanding of renal development, physiology and disease mechanisms as well as contributing to advances in the screening, diagnosis and management of kidney diseases.

  • Humanitarian crises in nephrology

    A series of articles focusing on global humanitarian challenges in nephrology that contribute to widespread disparities in kidney health, including issues related to social injustices and environmental protection.

  • Genetics kidney

    This series of articles aims to explore all aspects of nephrogenetics, from the genetics of monogenic diseases to complex traits and the interpretation and application of genetic and genomic data to improve patient outcomes

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    • Chronic kidney disease (CKD) is known to be associated with cognitive impairment, but the mechanisms that underlie this kidney–brain connection are unclear. A recent study provides evidence that CKD is an independent risk factor for cognitive decline due to cerebral small vessel disease.

      • Wei Ling Lau
      • Mark Fisher
      News & Views
    • Inter-organ interactions are critical for maintaining homeostasis in the body but can contribute to multi-organ dysfunction. Clinical evidence indicates that kidney dysfunction contributes to remote organ dysfunction, but little is known of the underlying mechanisms. Several reports published in 2022 identified critical mediators of kidney crosstalk with distant organs.

      • Sho Hasegawa
      • Reiko Inagi
      Year in Review
    • This Review discusses the mTORC1 and AMPK nutrient sensing pathways, their downstream effects in kidney cells, their roles in the development of kidney disease and the therapeutic potential of approaches that target these pathways in various chronic kidney diseases.

      • Christopher Huynh
      • Jaewhee Ryu
      • Ken Inoki
      Review Article
    • Gut microbiome studies have potential to provide novel therapeutic targets in chronic kidney disease. Here, the authors not only examine the current state of the field and discuss potential gut-related therapies for targeting uraemic metabolites, but also provide guidelines for improving microbiome study design, and data collection and analysis.

      • Hubert Krukowski
      • Sophie Valkenburg
      • Griet Glorieux
      Review Article
    • Disruptions in oxalate homeostasis can lead to kidney disease and cardiovascular complications. Here, the authors review the pathways that regulate oxalogenesis and the excretion of both exogenous and endogenous oxalate, consider the pathological effects of excess oxalate, and examine the latest therapeutic options for addressing oxalate dysregulation.

      • Theresa Ermer
      • Lama Nazzal
      • Felix Knauf
      Review Article

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