Models of drosophila

Drosophila melanogaster: a simple genetic model of kidney structure, function and disease

  • Julian A. T. Dow
  • Matias Simons
  • Michael F. Romero
Review Article


  • SARS-CoV-2 and the kidney

    This article series aims to highlight basic, clinical and psychological aspects of COVID-19 in nephrology as well as the impact of the pandemic on research and clinical trials.

  • Tools & technologies in nephrology

    A series of articles that aim to explore the tools and techniques that are improving our understanding of renal development, physiology and disease mechanisms as well as contributing to advances in the screening, diagnosis and management of kidney diseases.

  • Humanitarian crises in nephrology

    A series of articles focusing on global humanitarian challenges in nephrology that contribute to widespread disparities in kidney health, including issues related to social injustices and environmental protection.

  • Genetics kidney

    This series of articles aims to explore all aspects of nephrogenetics, from the genetics of monogenic diseases to complex traits and the interpretation and application of genetic and genomic data to improve patient outcomes


    • The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway not only is involved in host defence against infection but can lead to immune dysregulation. Here, the authors examine the biology and biochemistry of cGAS–STING and discuss its role in disease and potential approaches to therapeutic targeting.

      • Sladjana Skopelja-Gardner
      • Jie An
      • Keith B. Elkon
      Review Article
    • Hypoxia-dependent changes in cellular metabolism have important implications for the effective functioning of multiple immune cell subtypes. This Review describes the inputs that shape the hypoxic response in individual cell types and contexts, and the implications of this response for cellular metabolism and associated alterations in immune cell function.

      • Cormac T. Taylor
      • Carsten C. Scholz
      Review Article
    • Meaningful involvement of patients in clinical trial design could lead to improvements in participant recruitment and retention, the uptake of the tested intervention and the impact of the findings. Here, the authors discuss the involvement of patients at all stages of trial design.

      • Allison Tong
      • Nicole Scholes-Robertson
      • Jonathan C. Craig
      Review Article
    • In this Review, the authors discuss the roles of extracellular vesicles in kidney physiology and disease as well as the beneficial effects of stem cell-derived extracellular vesicles in preclinical models of acute kidney injury and chronic kidney disease. They also highlight current and future clinical applications of extracellular vesicles in kidney diseases.

      • Cristina Grange
      • Benedetta Bussolati
      Review Article
    • Chronic kidney disease is associated with an increased risk of cardiovascular disease, such as heart failure. Here, the authors examine myocardial metabolic remodelling in chronic kidney disease, including changes in energy substrate use, mitochondrial dysfunction and the role of cardiotonic steroids, and discuss potential metabolic therapies.

      • Nikayla Patel
      • Muhammad Magdi Yaqoob
      • Dunja Aksentijevic
      Review Article

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