Mechanisms of hypoxia signalling: new implications for nephrology

Latest Reviews

  • Perspective |

    This Perspectives article, written on behalf of the participants of the NIDDK Workshop on ‘Sex and the Kidneys’, considers opportunities for clinical, basic and translational research into sex differences in renal disease as well as the potential tools and resources needed to conduct this research.

    • C. Noel Bairey Merz
    • , Laura M. Dember
    • , Julie R. Ingelfinger
    • , Amanda Vinson
    • , Joel Neugarten
    • , Kathryn L. Sandberg
    • , Jennifer C. Sullivan
    • , Christine Maric-Bilkan
    • , Tracy L. Rankin
    • , Paul L. Kimmel
    •  & Robert A. Star
  • Review Article |

    Iron is essential for life but must be strictly regulated to avoid harmful effects. The authors discuss new insights into systemic and cellular iron handling with respect to renal physiology and pathology, current treatment practices and novel therapies for kidney disease.

    • Rachel P. L. van Swelm
    • , Jack F. M. Wetzels
    •  & Dorine. W. Swinkels
  • Perspective |

    The authors of this Perspectives article describe the physiological and statistical principles underlying measured glomerular filtration rate (mGFR) and estimated glomerular filtration rate (eGFR). They discuss their limitations, the circumstances under which mGFR and eGFR should be used, and approaches to improve these methodologies.

    • Andrew S. Levey
    • , Josef Coresh
    • , Hocine Tighiouart
    • , Tom Greene
    •  & Lesley A. Inker
  • Review Article |

    Fibroblast growth factor 23 (FGF23) is crucial to phosphate and calcium homeostasis. In this Review, the authors discuss how levels of biologically active FGF23 are controlled by balanced FGF23 transcription and protein cleavage, and how serum iron levels, inflammation and erythropoietin affect that balance.

    • Daniel Edmonston
    •  & Myles Wolf
  • Review Article |

    In this Review, the authors examine current efforts to develop a precision medicine approach that informs the diagnosis and treatment of patients with sepsis. Prognostic and predictive enrichment strategies in sepsis might also provide insight into the mechanisms that drive sepsis-associated acute kidney injury, a common complication of sepsis.

    • Natalja L. Stanski
    •  & Hector R. Wong
  • Review Article |

    Increasing evidence suggests that dysregulation of cellular metabolism has a role in the pathophysiology of autosomal dominant polycystic kidney disease. Here the authors discuss the underlying pathways and review efforts to use pharmacological interventions and lifestyle modifications to slow disease progression.

    • Luis Fernando Menezes
    •  & Gregory G. Germino

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