Mechanisms of haemolysis-induced kidney injury

Latest Reviews

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    Oncometabolites — conventional metabolites that, when aberrantly accumulated, have pro-oncogenic capabilities — have been implicated in renal cell carcinoma (RCC). Here, the authors review the role of oncometabolites in RCC, their origins and downstream effects and their potential applications as novel therapeutic targets and biomarkers.

    • Cissy Yong
    • , Grant D. Stewart
    •  & Christian Frezza
  • Perspective |

    This Perspectives article, written on behalf of the participants of the NIDDK Workshop on ‘Sex and the Kidneys’, considers opportunities for clinical, basic and translational research into sex differences in renal disease as well as the potential tools and resources needed to conduct this research.

    • C. Noel Bairey Merz
    • , Laura M. Dember
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    • , Amanda Vinson
    • , Joel Neugarten
    • , Kathryn L. Sandberg
    • , Jennifer C. Sullivan
    • , Christine Maric-Bilkan
    • , Tracy L. Rankin
    • , Paul L. Kimmel
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  • Review Article |

    Iron is essential for life but must be strictly regulated to avoid harmful effects. The authors discuss new insights into systemic and cellular iron handling with respect to renal physiology and pathology, current treatment practices and novel therapies for kidney disease.

    • Rachel P. L. van Swelm
    • , Jack F. M. Wetzels
    •  & Dorine. W. Swinkels
  • Perspective |

    The authors of this Perspectives article describe the physiological and statistical principles underlying measured glomerular filtration rate (mGFR) and estimated glomerular filtration rate (eGFR). They discuss their limitations, the circumstances under which mGFR and eGFR should be used, and approaches to improve these methodologies.

    • Andrew S. Levey
    • , Josef Coresh
    • , Hocine Tighiouart
    • , Tom Greene
    •  & Lesley A. Inker
  • Review Article |

    Fibroblast growth factor 23 (FGF23) is crucial to phosphate and calcium homeostasis. In this Review, the authors discuss how levels of biologically active FGF23 are controlled by balanced FGF23 transcription and protein cleavage, and how serum iron levels, inflammation and erythropoietin affect that balance.

    • Daniel Edmonston
    •  & Myles Wolf
  • Review Article |

    In this Review, the authors examine current efforts to develop a precision medicine approach that informs the diagnosis and treatment of patients with sepsis. Prognostic and predictive enrichment strategies in sepsis might also provide insight into the mechanisms that drive sepsis-associated acute kidney injury, a common complication of sepsis.

    • Natalja L. Stanski
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