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Key Advances in Nephrology

The February issue includes six Year in Review articles that address the successes and challenges of the past year.

Latest Issue

Latest Reviews

  • Review Article |

    Mitochondrial dysfunction has roles in acute kidney injury, chronic kidney disease and abnormal kidney repair. Here, the authors discuss the role of mitochondrial quality control mechanisms in kidney injury and repair and highlight their potential as therapeutic targets.

    • Chengyuan Tang
    • , Juan Cai
    • , Xiao-Ming Yin
    • , Joel M. Weinberg
    • , Manjeri A. Venkatachalam
    •  & Zheng Dong
  • Review Article |

    Clinical trials have demonstrated that glucagon-like peptide 1 receptor (GLP1R) agonists have therapeutic benefits beyond glycaemic control. Here, the authors examine the protective effects of incretin-based therapies in patients with diabetic kidney disease and how the immunomodulatory and anti-inflammatory effects of GLP1 might underlie this protection.

    • Radica Z. Alicic
    • , Emily J. Cox
    • , Joshua J. Neumiller
    •  & Katherine R. Tuttle
  • Review Article |

    Working towards sustainable development is essential to tackle the rise in the global burden of non-communicable diseases, including kidney disease. Five years after the Sustainable Development Goal agenda was set, this Review examines the progress thus far, highlighting future challenges and opportunities, and explores the implications for kidney disease.

    • Valerie A. Luyckx
    • , Ziyad Al-Aly
    • , Aminu K. Bello
    • , Ezequiel Bellorin-Font
    • , Raul G. Carlini
    • , June Fabian
    • , Guillermo Garcia-Garcia
    • , Arpana Iyengar
    • , Mohammed Sekkarie
    • , Wim van Biesen
    • , Ifeoma Ulasi
    • , Karen Yeates
    •  & John Stanifer
  • Review Article |

    Here, the authors describe the mechanisms of ultrafiltration during kidney replacement therapy, the effects of ultrafiltration on cardiovascular physiology and the principles of volume management in critically ill patients. They also discuss potential mechanisms that could underlie the association between ultrafiltration rate and organ dysfunction.

    • Raghavan Murugan
    • , Rinaldo Bellomo
    • , Paul M. Palevsky
    •  & John A. Kellum
  • Review Article |

    The molecular features that define the initiation and progression of clear cell renal cell carcinoma (ccRCC) are being increasingly defined. This Review summarizes common genomic and chromosomal copy number abnormalities in ccRCC, providing a mechanistic framework with which to organize these features into initiating events, drivers of progression and factors that confer lethality.

    • Eric Jonasch
    • , Cheryl Lyn Walker
    •  & W. Kimryn Rathmell
  • Review Article |

    This Review describes our current understanding of the pathogenic mechanisms involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the progression of coronavirus disease 2019 (COVID-19), focusing on the immunological hyper-response and the induction of widespread endothelial damage, complement-associated blood clotting and systemic microangiopathy, as well as the effects of these processes on the kidney. The authors also discuss therapeutic interventions that currently hold most promise.

    • Luca Perico
    • , Ariela Benigni
    • , Federica Casiraghi
    • , Lisa F. P. Ng
    • , Laurent Renia
    •  & Giuseppe Remuzzi

News & Comment

  • Comment |

    Insomnia is common among patients on maintenance haemodialysis and may be exacerbated by the challenges of the COVID pandemic. However, data on the efficacy of insomnia interventions in this population are limited. Efforts are needed to address this important problem and increase access to insomnia interventions for patients on haemodialysis.

    • Daniel Cukor
    • , Mark Unruh
    • , Susan M. McCurry
    •  & Rajnish Mehrotra
  • Comment |

    Regular physical activity can help people to live well with kidney disease, yet the promotion, funding, level of interest, and general support of physical activity remains poor. Novel high-quality approaches to increase physical activity must be considered, and practical means of scaling up effective interventions at the population level are required.

    • Thomas J. Wilkinson
    •  & Alice C. Smith
  • Comment |

    Older adults receiving dialysis commonly experience poor quality of life. A cyclical process of quality of life assessment, needs assessment and individualized care plans should be implemented to integrate quality of life into care planning. Improvements in health-care delivery and interpersonal communication are needed to prioritize quality of life.

    • Rasheeda K. Hall
  • Year in Review |

    Sodium–glucose co-transporter 2 inhibitors offer impressive cardiac and kidney outcome benefits to people with type 2 diabetes mellitus (T2DM). These benefits now appear to extend to people without T2DM, according to three trials published in 2020.

    • Amy Kang
    •  & Meg J. Jardine
  • Year in Review |

    Timely diagnosis and dialytic treatment of acute kidney injury (AKI) came to the forefront at the height of the coronavirus disease 2019 pandemic as admissions surged in intensive care units. Research on early diagnosis, timing of initiation of kidney replacement therapy, and appropriate post-hospitalization patient care remains essential to tackling the burden of AKI.

    • Anitha Vijayan
  • Year in Review |

    The COVID-19 pandemic and the Movement for Black Lives have focused attention on racial disparities in kidney health outcomes. In 2020, kidney professionals highlighted threats posed by racism and other negative social drivers of kidney health, and proposed solutions to address these issues through scholarship and advocacy for social justice.

    • O. N. Ray Bignall II
    •  & Deidra C. Crews


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