Lara Crow

Central nervous system neuroplasticity and the sensitization of hypertension

Latest Reviews

  • Review Article |

    Autoimmune diseases and kidney transplantation can result in immune-mediated kidney pathology. In this Review, the authors discuss the roles of effector and regulatory B cells and the efficacy of B cell-targeting therapies in these settings.

    • Kristine Oleinika
    • , Claudia Mauri
    •  & Alan D. Salama
  • Review Article |

    The complement system has a key role in inflammatory reactions that occur before, during and after transplantation. Here, the authors discuss this role and highlight current and future strategies to regulate complement activation and potentially improve outcomes in kidney transplantation.

    • Ali-Reza Biglarnia
    • , Markus Huber-Lang
    • , Camilla Mohlin
    • , Kristina N. Ekdahl
    •  & Bo Nilsson
  • Review Article |

    This Review focuses on the epidemiology, pathogenesis and treatment of dyslipidaemia in patients with chronic kidney disease (CKD) and end-stage renal disease. The authors discuss emerging clinical data on the use of novel lipid-lowering agents and reappraise the 2013 KDIGO Guidelines for Lipid Management in CKD.

    • Charles J. Ferro
    • , Patrick B. Mark
    • , Mehmet Kanbay
    • , Pantelis Sarafidis
    • , Gunnar H. Heine
    • , Patrick Rossignol
    • , Ziad A. Massy
    • , Francesca Mallamaci
    • , Jose M. Valdivielso
    • , Jolanta Malyszko
    • , Marianne C. Verhaar
    • , Robert Ekart
    • , Raymond Vanholder
    • , Gerard London
    • , Alberto Ortiz
    •  & Carmine Zoccali
  • Review Article |

    Here, Johnson and Xue describe various physiological and psychosocial challenges that lead to the sensitization of hypertension. These challenges drive neuroplasticity in the brain network controlling sympathetic tone and blood pressure, and provide a new paradigm for understanding essential hypertension.

    • Alan Kim Johnson
    •  & Baojian Xue
  • Review Article |

    Here, Lam and colleagues review advances in understanding the pathogenesis of tuberous sclerosis complex (TSC). Although rapalogues are effective cytostatic treatments for TSC, the unique metabolic vulnerabilities of cells lacking hamartin and/or tuberin might represent opportunities for developing cytocidal treatments.

    • Hilaire C. Lam
    • , Brian J. Siroky
    •  & Elizabeth P. Henske
  • Review Article |

    Acute kidney injury (AKI) is a life-threatening complication in critically-ill neonates. This Review explores the evidence that intrauterine growth restriction, premature birth and low birth weight contribute to neonatal AKI, and discusses perinatal and postnatal risk factors that enhance the risk of AKI among neonates.

    • Norberto Perico
    • , David Askenazi
    • , Monica Cortinovis
    •  & Giuseppe Remuzzi

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