A droplet of water

Long-term health outcomes associated with hydration status

  • Natalia I. Dmitrieva
  • Manfred Boehm
  • Sofia Enhörning
Review Article


  • Webinar advertisement

    Watch the recording of our webinar on "Digital Determinants of Health: AI and the need for equity-focused innovation in digital health" with Leo Celi and Kianoush Kashani.

  • A toolbox

    A series of articles that aim to explore the tools and techniques that are improving our understanding of renal development, physiology and disease mechanisms as well as contributing to advances in the screening, diagnosis and management of kidney diseases.

  • A kidney puzzle

    This Focus issue examines how tackling the three dimensions of sustainable development — social, economic and environmental — is essential to improving global kidney health.


    • In this Review, the authors summarize the mechanistic rationale for current treatments for podocytopathies and for novel podocyte-targeted therapies. They also discuss potential approaches to regenerate podocytes and to develop podocyte-specific drug delivery systems.

      • Kristin Meliambro
      • John C. He
      • Kirk N. Campbell
      Review Article
    • Spatially resolved transcriptomic technologies enable the mapping of transcripts at single-cell or near single-cell resolution in a multiplex manner. This Review describes current and emerging spatial transcriptomic methods, their applications of relevance to kidney biology and remaining challenges for the field.

      • Sanjay Jain
      • Michael T. Eadon
      Review Article
    • Here, the authors discuss the beneficial effects of sodium–glucose cotransporter 2 (SGLT2) inhibitors for a range of clinical outcomes beyond glucose lowering, including kidney and cardiovascular protection. They also discuss the need for implementation and adherence initiatives to help translate the benefits of these agents into real-world clinical outcomes.

      • Daniel V. O’Hara
      • Carolyn S. P. Lam
      • Meg J. Jardine
      Review Article
    • Chronic kidney disease (CKD) is associated with several alterations in protein post-translational modifications. Here, the authors examine the evidence of these alterations, their links with CKD progression and cardiovascular risk in patients with CKD, and their potential clinical applications.

      • Heidi Noels
      • Vera Jankowski
      • Joachim Jankowski
      Review Article
    • A new study describes the development of proteomics-based ageing clocks that calculate the biological age of specific organs and define features of extreme ageing associated with age-related diseases. Their findings support the notion that plasma proteins can be used to monitor the ageing rates of specific organs and disease progression.

      • Khaoula Talbi
      • Anette Melk
      News & Views
  • Kidney disease is strongly linked with cardiovascular diseases, hypertension, diabetes, infections and other health conditions, as well as social determinants of health and climate change. Consequently, a holistic approach to promote well-being, protect individual health and improve access to quality primary care will support kidney health.

    • Slim Slama
    • Valerie A. Luyckx
    • Bianca Hemmingsen
  • Chronic kidney disease is a life-changing diagnosis for millions of people worldwide, as the risk of disease progression and kidney failure creates unbearable uncertainty and limits lifestyle. The devastating impact of advanced kidney disease must be acknowledged in the public health agenda to pave way for improved outcomes for patients at all stages of disease.

    • Daniel Gallego
  • Clinical algorithms that are used to guide medical decision-making often include sex as a variable. However, binary considerations of sex and/or gender might introduce bias due to potentially inaccurate assumptions about sex and gender-specific physiology, hormones and exposures. An equity-focused approach to sex and gender is essential when using clinical algorithms to ensure health equity across populations.

    • Dinushika Mohottige
    • Samira Farouk
    • Selma Feldman Witchel
  • Clinical trial data suggest that thiazides and thiazide-like drugs could be beneficial for blood-pressure lowering in patients with severe chronic kidney disease. However, prolonged exposure to these photosensitizing drugs could translate into increased risk of squamous cell carcinoma and post-transplant diabetes in the already extremely vulnerable kidney transplant population.

    • Steven Van Laecke