Lara Crow

Intravenous fluid therapy in critically ill adults

Latest Reviews

  • Review Article |

    In this Review, Caplan and colleagues describe the metabolic alterations in autosomal dominant polycystic kidney disease and how these might be novel therapeutic targets in the treatment of polycystic kidney disease.

    • Valeria Padovano
    • , Christine Podrini
    • , Alessandra Boletta
    •  & Michael J. Caplan
  • Review Article |

    The application of precision gene editing has great potential to accelerate basic research and advance clinical practice in nephrology. Here, the authors discuss this technology and the challenges and potential of genome editing in the kidney.

    • Zachary WareJoncas
    • , Jarryd M. Campbell
    • , Gabriel Martínez-Gálvez
    • , William A. C. Gendron
    • , Michael A. Barry
    • , Peter C. Harris
    • , Caroline R. Sussman
    •  & Stephen C. Ekker
  • Review Article |

    This Review updates the evidence base for the administration of intravenous fluids to critically ill patients. Finfer and colleagues also discuss unresolved questions, such as whether buffered solutions are better than normal saline, and the benefits and harms of restrictive approaches to fluid administration.

    • Simon Finfer
    • , John Myburgh
    •  & Rinaldo Bellomo
  • Review Article |

    Immune checkpoint inhibitors (ICIs) have led to a paradigm shift in cancer therapy; however, these agents can induce immune-related adverse events (irAEs) in off-target organs. This Review describes the mechanism of action of ICI therapies and how these agents induce irAEs in the kidney and heart.

    • Krishna Sury
    • , Mark A. Perazella
    •  & Anushree C. Shirali
  • Review Article |

    Improved understanding of HLAs together with advances in HLA typing and antibody detection techniques have enabled transplantation of sensitized patients. Here, the authors discuss these advances as well as novel approaches to desensitization, immunomodulation and tolerance induction.

    • Robert A. Montgomery
    • , Vasishta S. Tatapudi
    • , Mary S. Leffell
    •  & Andrea A. Zachary
  • Perspective |

    This Perspectives article describes supporting and contradicting data regarding the role of podocyte B7-1 in the pathogenesis of various podocytopathies and highlights issues that need to be addressed to standardize approaches to the study of this protein.

    • Rubina Novelli
    • , Ariela Benigni
    •  & Giuseppe Remuzzi

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