Carl Conway

Environmental pollution and kidney diseases

Latest Reviews

  • Review Article |

    Dysfunction of one or more organs is a common occurrence in patients with sepsis owing to microcirculatory alterations and cellular dysfunction. In this Review, the authors summarize knowledge of the mechanisms that underlie organ failure in sepsis and discuss how these insights are providing targets for the treatment of sepsis.

    • Christophe Lelubre
    •  & Jean-Louis Vincent
  • Review Article |

    Patients who present with chronic kidney disease and diabetes mellitus can have true diabetic kidney disease (DKD), nondiabetic kidney disease (NDKD), or a combination of both DKD and NDKD. Here, Anders and colleagues discuss the mechanisms underlying these entities and how greater appreciation of distinctions between these entities might facilitate the development of new treatments.

    • Hans-Joachim Anders
    • , Tobias B. Huber
    • , Berend Isermann
    •  & Mario Schiffer
  • Review Article |

    Current in vitro nephrotoxicity screens are poorly predictive of toxicity in humans. Here, the authors describe mechanisms of nephrotoxic injury, the functional features of tubular cell models that are essential for predicting the toxicity of pharmaceutical compounds, and novel in vitro cell models under development.

    • Joanne Y.-C. Soo
    • , Jitske Jansen
    • , Rosalinde Masereeuw
    •  & Melissa H. Little
  • Review Article |

    Angiotensin-converting enzyme (ACE) not only plays a major part in the regulation of blood pressure but also participates in several other physiological functions, including renal development and male reproduction. Here, Bernstein et al. discuss how ACE enhances both innate and adaptive responses by modulating macrophage and neutrophil function.

    • Kenneth E. Bernstein
    • , Zakir Khan
    • , Jorge F. Giani
    • , Duo-Yao Cao
    • , Ellen A. Bernstein
    •  & Xiao Z. Shen
  • Review Article |

    Renal dysfunction and atrial fibrillation (AF) share common risk factors and often coexist. Here, the authors discuss the risks and benefits of use of vitamin K antagonists (VKAs) and non-VKA oral anticoagulants for thromboprophylaxis in patients with coexistent AF and renal dysfunction.

    • Tatjana S. Potpara
    • , Charles J. Ferro
    •  & Gregory Y. H. Lip
  • Review Article |

    Exposure to environmental pollutants is a major cause of kidney injury and disease worldwide and is a particular problem in the developing world. In this Review, the authors discuss the different environmental pollutants that affect the kidney, and our understanding of the pathogenic mechanisms of environmental pollutants in kidney injury and disease.

    • Xin Xu
    • , Sheng Nie
    • , Hanying Ding
    •  & Fan Fan Hou

News & Comment

  • News & Views |

    Two new clinical trials together involving nearly 30,000 patients support previous observational evidence that the most common solution used for intravenous fluid therapy in the world is associated with kidney damage. Both trials found that 0.9% saline was inferior to solutions with more physiological chloride concentrations and resulted in greater rates of major adverse kidney events.

    • John A. Kellum
  • News & Views |

    A recent observational study reports that implantable cardioverter defibrillators were not associated with improved survival in patients with heart failure, reduced left ventricular ejection fraction and chronic kidney disease. Further studies are needed to identify which of these high-risk patients are most likely to benefit from this potentially life-saving therapy.

    • Finnian R. Mc Causland
    •  & Marc A. Pfeffer
  • News & Views |

    A genome-wide association study (GWAS) of quantitative traits that incorporated data from GWAS of complex diseases provides clues regarding the relationships between genetic loci, intermediate phenotypes and diseases. Together, the data demonstrate pleiotropy, genetic correlation and cell-type specificity of quantitative traits as predictors of multiple complex diseases.

    • David L. Mattson

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