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TREK1 is the most extensively studied of the mammalian two-pore-forming K+channels and is widely expressed in the brain. Honoré reviews the functional properties of TREK1 and describes recent results indicating its important roles in CNS function and disease.
Memory reconsolidation theory is the subject of intensive recent research and debate. Tronson and Taylor outline the molecular events implicated in this process and discuss how elucidating its mechanisms could improve our understanding of normal and abnormal memory function.
The basic principles of colour vision have been understood for a long time, but recent studies have revealed the processes underlying it in more detail. Lennie and Solomon review our current understanding of colour processing, from cones to the primary visual cortex.
Agenesis of the corpus callosum (AgCC) shares anatomical and behavioural features with certain neurodevelopmental and psychiatric disorders. Providing insight into the developmental and molecular basis of AgCC, Lynn Paul and colleagues explain why AgCC may be a good model for other brain disorders.
Humans punish selfishly but also altruistically. Seymour, Singer and Dolan propose a neurobiological model of punishment based on our understanding of motivational systems, observational studies that show how punishment mediates cooperation, and brain imaging data from humans playing economic games.
Loss of aligned glial pathways may contribute to the inability of axons to successfully regenerate following CNS injury. Raisman and Li discuss why transplantation of olfactory ensheathing cells might be a promising strategy to re-establish these pathways and restore function.
