Volume 24 Issue 2, February 2023

Deletion of Gabrb3, which encodes the β3 subunit of the GABA_A receptor selectively in pyramidal neurons of developing mouse sensory cortex, increased contralateral connectivity, network synchrony and sensitivity to tactile stimuli, suggesting that this receptor is involved in refinement of interhemispheric sensory pathways.

Hyperactivity in a subset of lateral septum neurons inhibits social reward processing and drives social avoidance following chronic social defeat in mice.

Ketamine-induced dissociated states in mice result from the suppression and activation of cortical pyramidal neuron populations that are active and silent during wakefulness, respectively.

In this Journal Club, Xiang Yu describes a 1986 study that provided crucial evidence for synaptic pruning in cortical development.

Schemas are structured bodies of prior knowledge that reflect common patterns of information from related experiences. In this Review, Farzanfar et al. discuss evidence for spatial schemas, how they form and how they differ from cognitive maps.

Cortical inhibitory interneurons undergo diverse forms of long-term synaptic plasticity. In this Review, Sjöström and colleagues describe the diversity of this interneuron plasticity and highlight that the plasticitome, a comprehensive database of plasticity rules, is needed to understand circuit plasticity complexity.

When humans attempt two tasks at once, there are costs to task performance. In this Perspective, Garner and Dux discuss neurophysiological evidence for whether these multitasking costs are linked to the human capability for rapid knowledge generalization to perform novel tasks.

Neural oscillations are thought to have an important role in syntactic structure building but views differ on their exact function in this context. In this Perspective, Kazanina and Tavano explore two proposed functions for neural oscillations in this process, namely chunking and multiscale information integration.