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A study in mice finds that different dopamine neuron subsystems in the midbrain track food and fluid ingestion at different stages of this process, and that animals can use this information to learn about the results of ingestion.
Dynamin mediates vesicle scission during endocytosis, and here is shown to exist with syndapin 1 in biomolecular condensates at the endocytic zone that enable its participation in ultrafast endocytosis.
Pathological forms of amyloid proteins, such as tau and α-synuclein, are thought to drive neurodegeneration. Li and Liu describe how techniques that reveal high-resolution protein structures can provide insight into polymorphic amyloid fibril formation and the relationships between amyloid protein conformation and disease.
Social valence — the valence assigned to a social agent or social stimulus — is complex to compute. In this Review, Padilla-Coreano et al. explain how social attributes, social history, social memory, social rank and social isolation states are integrated to modulate social valence assignment.
In this Review, Panzeri, Moroni, Safaai and Harvey explain how the levels and structures of correlations among the activity of neurons in a population shape information encoding, transmission and readout, and describe how future research could determine how the structures of correlations are optimized.
When anticipating a threat, many animals ‘freeze’, becoming temporarily immobile. Roelofs and Dayan argue that this response enables the coordination of cognitive and somatic processes that prepare the animal for action and describe how CNS, autonomic and sensorimotor activity must be integrated to regulate freezing.
