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Volume 22 Issue 3, March 2021

‘On the same wavelength’, inspired by the Perspective on p181.

Cover design: Jennie Vallis.

Research Highlights

  • Projections from the anterior cingulate cortex to the nucleus accumbens are required for the social transfer of pain or analgesia in mice.

    • Darran Yates
    Research Highlight

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  • In flies, neurons that are common to both sexes regulate aggressive approach, whereas other, sex-specific neurons control attack behaviours.

    • Natasha Bray
    Research Highlight
  • The innate responses of mice to sweet-tasting or bitter-tasting stimuli can be modulated by top-down feedback from the cortex.

    • Katherine Whalley
    Research Highlight
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Reviews

  • The molecular basis of trans-synaptic signalling by Neurexins plays an important role in synapse organization. In this Review, Scheiffele and colleagues link cell type-specific alternative splicing to the combinatorial action of Neurexin isoforms, and provide a mechanistic framework for Neurexin functions in synapse organization.

    • Andrea M. Gomez
    • Lisa Traunmüller
    • Peter Scheiffele
    Review Article
  • A substantial burden of neurological disease is related to mutations in three sodium channel genes: SCN1A, SCN2A and SCN8A. In this Review, Meisler and colleagues discuss the neurological disorders associated with these mutations and also the therapeutic opportunities that are being investigated as a result of these recent mechanistic insights.

    • Miriam H. Meisler
    • Sophie F. Hill
    • Wenxi Yu
    Review Article
  • Flexibility is critical for the optimal adaptation of thoughts and actions under changing circumstances. In this Review, Uddin summarizes research that has identified cognitive processes and neural systems supporting flexibility and discusses ways to improve flexibility across the lifespan.

    • Lucina Q. Uddin
    Review Article
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Perspectives

  • The role of the default mode network (DMN) is unclear. In this Perspective, Yeshurun, Nguyen and Hasson review evidence that the DMN integrates extrinsic inputs with intrinsic information over long timescales, enabling it to represent meaning in a way that can be shared between individuals.

    • Yaara Yeshurun
    • Mai Nguyen
    • Uri Hasson
    Perspective
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