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In this open letter, co-founders of the Black In Neuro initiative thank previous mentors and advise future mentors on how to effectively encourage the next generation of Black researchers.
Ecotopic expression of three transcription factors induces reprogramming of the DNA methylation pattern of aged or injured retinal ganglion cells to a more ‘youthful’ state.
Local mRNA translation is essential for the function of polarized cells, such as neurons. Twiss and colleagues provide an overview of the cellular mechanisms that coordinate the transport and translation of axonal mRNAs, allowing the axon to respond to changing physiological demands.
The cerebellum has an established role in procedural learning; however, the mechanisms through which it mediates learning are less well understood. De Zeeuw describes evidence for the existence of ‘upbound’ and ‘downbound’ microzones of cerebellar Purkinje cells and considers how they contribute to different forms of cerebellar learning.
Lewy bodies, which are α-synuclein-rich intracellular inclusions, are pathological hallmarks of several neurodegenerative diseases, notably Parkinson disease. In this Review, Fares, Jagannath and Lashuel examine the biochemical, structural and morphological features of Lewy bodies as well as how α-synuclein pathology may form and spread.