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Volume 22 Issue 2, February 2021

‘Ups and downs’ inspired by the Review on p92.

Cover design: Jennie Vallis.

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Research Highlights

  • Ecotopic expression of three transcription factors induces reprogramming of the DNA methylation pattern of aged or injured retinal ganglion cells to a more ‘youthful’ state.

    • Natasha Bray
    Research Highlight
  • Downward homeostatic regulation of neuronal firing rate in the visual cortex occurs via synaptic scaling and is enabled by sleep.

    • Katherine Whalley
    Research Highlight
  • A new study provides evidence suggesting that SARS-CoV-2 may be able to enter the CNS via the neural–mucosal interface in the olfactory mucosa.

    • Darran Yates
    Research Highlight
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Reviews

  • Local mRNA translation is essential for the function of polarized cells, such as neurons. Twiss and colleagues provide an overview of the cellular mechanisms that coordinate the transport and translation of axonal mRNAs, allowing the axon to respond to changing physiological demands.

    • Irene Dalla Costa
    • Courtney N. Buchanan
    • Jeffery L. Twiss
    Review Article
  • The cerebellum has an established role in procedural learning; however, the mechanisms through which it mediates learning are less well understood. De Zeeuw describes evidence for the existence of ‘upbound’ and ‘downbound’ microzones of cerebellar Purkinje cells and considers how they contribute to different forms of cerebellar learning.

    • Chris I. De Zeeuw
    Review Article
  • Lewy bodies, which are α-synuclein-rich intracellular inclusions, are pathological hallmarks of several neurodegenerative diseases, notably Parkinson disease. In this Review, Fares, Jagannath and Lashuel examine the biochemical, structural and morphological features of Lewy bodies as well as how α-synuclein pathology may form and spread.

    • Mohamed Bilal Fares
    • Somanath Jagannath
    • Hilal A. Lashuel
    Review Article
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