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Gina Poe and Denise Cai reflect on the challenges to research team management presented by the widespread closure of laboratories during the COVID-19 pandemic and consider the unexpected opportunities that have arisen from the lockdown
In the hippocampus of adult mice, neuronally expressed interleukin-33 acts as a signal for microglial cell-mediated extracellular matrix remodelling, regulating synaptic plasticity and promoting memory consolidation.
The activity of a subset of projections neurons in the song premotor nucleus HVC of canaries depends on preceding steps in the bird’s song and can predict future song phrases.
Postnatal brain development is highly influenced by sensory experience, in part via de novo activation of enhancer sequences by inducible transcription factors.
Activation of mitochondrial cannabinoid 1 receptors in mouse astrocytes disrupts astrocyte metabolism, bioenergetic support for neurons and social behaviour.
A number of spatially selective neurons that encode an animal’s distance and direction from environmental features have been proposed by theoretical studies and experimentally identified. Andrej Bicanski and Neil Burgess summarize our current understanding of vector coding cells and describe their contribution to spatial cognition.
The causal role of chromatin modifications has been difficult to study in the brains of behaving animals. Yim, Teague and Nestler review locus-specific neuroepigenome-editing tools to define causal relationships between chromatin modifications and their molecular, cellular, circuit and behavioural consequences.
Satellite glial cells surround the cell bodies of neurons in peripheral ganglia and are activated by numerous types of nerve injury and inflammation. In this Review, Hanani and Spray discuss the cellular changes in these cells that contribute to four common types of pain.
Increasing evidence indicates that some cortical neurons that send long-range projections to distant brain regions are GABAergic. In this Review, Melzer and Monyer examine recent progress in the identification and function of these neurons.
