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Volume 20 Issue 12, December 2019

Volume 20 Issue 12

‘Bright sparks’ inspired by the Review on p719

Cover design: Jennie Vallis.

Research Highlights

  • Research Highlight |

    Dendritic activation and action potentials lead to the expression of distinct heterodimers of the inducible transcription factor NPAS4, which show distinct DNA binding patterns; these patterns were recapitulated on exposure of mice to a novel environment.

    • Sian Lewis
  • Research Highlight |

    Three studies show that synaptic interactions between neurons and glioma cells or cells of breast-cancer-to-brain metastases may promote tumour growth.

    • Natasha Bray
  • Research Highlight |

    A population of hypothalamic neurons that are active during REM sleep are involved in forgetting.

    • Katherine Whalley


  • Review Article |

    In individuals with inflammation of the central nervous system, B cells enter and accumulate in the cerebrospinal fluid, brain parenchyma and perivascular spaces. Here, Joseph Sabatino and colleagues review the contributions of B cells — both in the periphery and sequestered within the central nervous system — to the pathogenesis of several autoimmune and neurodegenerative diseases.

    • Joseph J. Sabatino Jr
    • Anne-Katrin Pröbstel
    • Scott S. Zamvil
  • Review Article |

    The complex spatiotemporal organization and regulation of sleep-related brain activity has been appreciated only in the past decade. Here, Adamantidis and colleagues review neurobiological mechanisms underlying local and large-scale neuronal network oscillations in the sleeping mammalian brain and how they relate to the global architecture of sleep.

    • Antoine R. Adamantidis
    • Carolina Gutierrez Herrera
    • Thomas C. Gent
  • Review Article |

    Emerging data suggest a key role for dopamine in the perceptual disturbances that occur in psychotic disorders. In this Review, Horga and Abi-Dargham discuss a framework focused on perceptual inference, emphasizing the role of dopamine and the relevant associative cortico–striatal circuits.

    • Guillermo Horga
    • Anissa Abi-Dargham


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