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Recording from neuronal populations is a promising and powerful neuroscience technique; however, interpreting the resulting spike trains presents several challenges. Quian Quiroga and Panzeri discuss how decoding algorithms and information theory can be used to extract information from population recordings.
In recent years, the principles of network science have increasingly been applied to the study of the brain's structural and functional organization. Bullmore and Sporns review this growing field of research and discuss its contributions to our understanding of brain function.
In this Review, Imeri and Opp describe how interactions between cytokines and the serotonin system contribute to the regulation of both normal sleep and the sleep alterations that occur during infection, and discuss the possible adaptive function of altered sleep during sickness.
The locus coeruleus (LC) is the sole source of noradrenaline in the forebrain. Susan Sara revisits the early theories of the function of the LC noradrenaline system and discusses recent data that implicate this system in sensory processing, learning and memory.
Do remote memories re-stabilize after reactivation? Nader and Hardt analyse data and interpretations from consolidation and reconsolidation studies and establish that newly acquired and reactivated remote memories share almost all of their basic characteristics, concluding that reconsolidation restores reactivated memories.
The effects of the glial scar on regeneration after injury have traditionally been viewed as inhibitory. Schwartz and colleagues discuss the evidence that scar tissue can have a beneficial role in the repair process and propose that the timing of scar generation and degradation is crucial in determining its effects.