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Catalytically inactive scaffold proteins are major constituents of the postsynaptic density. Feng and Zhang describe the distinct binding properties of multi-PDZ-domain-containing scaffold proteins that enable them to actively participate in the dynamic regulation of signalling events at the synapse.
DNA repair pathways are essential for normal nervous system development and function. McKinnon reviews the mechanisms of DNA damage and repair in the nervous system and how deficits in these pathways cause specific neuropathological symptoms.
Most models of sensory processing consider the spatial and temporal aspects of sensory stimuli separately. Here, Buonomano and Maass describe a framework in which spatiotemporal computations emerge from the interaction between incoming stimuli and the internal dynamic state of neural networks.
A number of transgenic mouse strains show enhanced learning and memory. Silva and Lee analyse the molecular pathways affected in these mice, highlighting the central role of the NMDA receptor, the transcription factor CREB and long-term potentiation.
Models of conflict-induced behavioural adjustment suggest that the anterior cingulate cortex and the dorsolateral prefrontal cortex have specific roles in this process. Mansouri and colleagues discuss and provide an update of these models based on recent human and animal data.
The existence of neural stem cells (NSCs) in the walls of the lateral ventricle is well known, yet debate about the precise identity of these cells continues. Weiss and colleagues describe tools used to study NSCs and consider the controversies in the field.
