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Volume 10 Issue 2, February 2009

Volume 10 Issue 2

From The Editors

Research Highlight

In Brief

Research Highlight

In Brief

Research Highlight

In the News

Review Article

  • Review Article |

    Catalytically inactive scaffold proteins are major constituents of the postsynaptic density. Feng and Zhang describe the distinct binding properties of multi-PDZ-domain-containing scaffold proteins that enable them to actively participate in the dynamic regulation of signalling events at the synapse.

    • Wei Feng
    • Mingjie Zhang
  • Review Article |

    DNA repair pathways are essential for normal nervous system development and function. McKinnon reviews the mechanisms of DNA damage and repair in the nervous system and how deficits in these pathways cause specific neuropathological symptoms.

    • Peter J. McKinnon
  • Review Article |

    Most models of sensory processing consider the spatial and temporal aspects of sensory stimuli separately. Here, Buonomano and Maass describe a framework in which spatiotemporal computations emerge from the interaction between incoming stimuli and the internal dynamic state of neural networks.

    • Dean V. Buonomano
    • Wolfgang Maass
  • Review Article |

    A number of transgenic mouse strains show enhanced learning and memory. Silva and Lee analyse the molecular pathways affected in these mice, highlighting the central role of the NMDA receptor, the transcription factor CREB and long-term potentiation.

    • Yong-Seok Lee
    • Alcino J. Silva



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