November 2016

Molecular mechanisms of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that primarily targets vulnerable motor neurons, resulting in muscle weakness and fatal paralysis.

March 2016

The immunology and neurobiology of multiple sclerosis

Multiple sclerosis (MS) is a neuroinflammatory condition that affects the central nervous system and presents with various neurological and cognitive symptoms.

October 2015

Control of sleep in mammals

n most mammalian species, sleep can be divided into phases of rapid eye movement (REM) sleep and non-REM sleep.

July 2015

Cell-reprogramming technology and neuroscience

Advances in cell-reprogramming technology have made it possible to convert differentiated cells of one type into cells of a completely different origin and function, either directly or via the production of induced pluripotent stem cells.

December 2013

BDNF function in health and disease

Brain-derived neurotrophic factor (BDNF) is the most widely expressed and well-characterized member of the neurotrophin family in the mammalian brain.

August 2010

Neural regulation of food intake and energy balance

The obesity epidemic has stimulated research to improve our understanding of how the brain regulates energy balance and food intake, and to identify potential targets for anti–obesity drugs. In the past few decades, numerous molecules have been implicated in the regulation of energy balance.

May 2008

Amyloid-β and tau in Alzheimer's disease

Alzheimer's disease (AD) is a devastating neurodegenerative disorder with a relentless progression.

April 2007

Pain mechanisms

Pain is an unpleasant sensation resulting from the intricate interplay between sensory and cognitive mechanisms.

June 2005

Integrated biochemical signalling in postsynaptic spines

Adjustments in the strength of excitatory synapses in neural networks are important for memory storage and maintenance of homeostasis in the brain.