Molecular mechanisms of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that primarily targets vulnerable motor neurons, resulting in muscle weakness and fatal paralysis.
The immunology and neurobiology of multiple sclerosis
Multiple sclerosis (MS) is a neuroinflammatory condition that affects the central nervous system and presents with various neurological and cognitive symptoms.
Control of sleep in mammals
n most mammalian species, sleep can be divided into phases of rapid eye movement (REM) sleep and non-REM sleep.
Cell-reprogramming technology and neuroscience
Advances in cell-reprogramming technology have made it possible to convert differentiated cells of one type into cells of a completely different origin and function, either directly or via the production of induced pluripotent stem cells.
BDNF function in health and disease
Brain-derived neurotrophic factor (BDNF) is the most widely expressed and well-characterized member of the neurotrophin family in the mammalian brain.
Neural regulation of food intake and energy balance
The obesity epidemic has stimulated research to improve our understanding of how the brain regulates energy balance and food intake, and to identify potential targets for anti–obesity drugs. In the past few decades, numerous molecules have been implicated in the regulation of energy balance.
Amyloid-β and tau in Alzheimer's disease
Alzheimer's disease (AD) is a devastating neurodegenerative disorder with a relentless progression.
Pain is an unpleasant sensation resulting from the intricate interplay between sensory and cognitive mechanisms.
Integrated biochemical signalling in postsynaptic spines
Adjustments in the strength of excitatory synapses in neural networks are important for memory storage and maintenance of homeostasis in the brain.