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In the hippocampus of adult mice, neuronally expressed interleukin-33 acts as a signal for microglial cell-mediated extracellular matrix remodelling, regulating synaptic plasticity and promoting memory consolidation.
Gina Poe and Denise Cai reflect on the challenges to research team management presented by the widespread closure of laboratories during the COVID-19 pandemic and consider the unexpected opportunities that have arisen from the lockdown
Although neuroscientists focus on only very few animal species today, there are many important reasons to take advantage of model system diversity and embrace (anew) a comparative approach in modern brain research. Recent technological advances make this increasingly possible.