Articles in 2023

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  • A mark test of self-recognition in mice reveals that self-responding ventral CA1 neurons underlie mirror-induced self-directed behaviour and are shaped by social experience with conspecifics.

    • Jake Rogers
    Research Highlight
  • A small population of neurons in the mouse brainstem coordinate sound production and volume control during vocalizations.

    • Katherine Whalley
    Research Highlight
  • A study in mice helps to resolve a debate surrounding striatal DA dynamics and reward benefit or cost and also reveals motivation and transient striatal DA release have a bidirectional causal relationship.

    • Jake Rogers
    Research Highlight
  • In mice, specific pools of adult neural stem cells are recruited during pregnancy to support postpartum maternal behaviour.

    • Katherine Whalley
    Research Highlight
  • SARS-CoV-2 infection is associated with various neurological effects both during and after infection. In this Review, Meinhardt and colleagues discuss the possible impact of SARS-CoV-2 infection on different cell populations of the nervous system and the neurological alterations that result, thus facilitating the development of treatment options.

    • Jenny Meinhardt
    • Simon Streit
    • Frank L. Heppner
    Review Article
  • A prevailing notion in sleep research is that sleep homeostasis and circadian rhythmicity involve independent processes. In this Review, Franken and Dijk discuss evidence that suggests that sleep and circadian rhythmicity are interdependent and together support the homeostasis of brain function.

    • Paul Franken
    • Derk-Jan Dijk
    Review Article
  • Ongoing systemic and neurocognitive impairments that continue in a subset of individuals after infection with SARS-CoV-2 infection are found to be associated with reduced serotonin levels.

    • Sian Lewis
    Research Highlight
  • Neurobiological organizational principles suggest that a generative grammar exists in the brain. In this Perspective, Dragoi proposes how neural grammar enables specific experience-independent, internally generated patterns of activity acquired via spontaneous generative combination of pre-existing sequential motifs to support internally generated representations of experience in the hippocampus.

    • George Dragoi
    Perspective
  • In mice, localized mutant APP expression in the CA3 hippocampal region leads to progressive network dysfunction and hippocampus-dependent memory deficits.

    • Darran Yates
    Research Highlight
  • Human cortical neurons undergo a protracted period of postmitotic maturation compared with those of other species. Wallace and Pollen review the cell-intrinsic and cell-extrinsic mechanisms that govern neuronal postmitotic development and consider the factors that may contribute to species-specific maturation rates.

    • Jenelle L. Wallace
    • Alex A. Pollen
    Review Article
  • A new biotinylation-based approach identifies previously unknown cell surface proteins of the axonal initial segment (AIS) and shows a role for contactin-1 in assembly of the AIS extracellular matrix.

    • Lisa Heinke
    Research Highlight
  • The organization and diversity of neuronal and glial primary cilia and their connectivity in the human cortex is characterized in detail.

    • Katherine Whalley
    Research Highlight
  • Fluorescent indicators can provide quantitative insights into the spatiotemporal dynamics of signalling molecules released by brain circuits. However, a mismatch between the experimental context and the experimental imaging settings often introduces unexpected errors and biases in such measurements. Appreciating this mismatch should help to arrive at unbiased estimates.

    • Dmitri A. Rusakov
    Comment
  • The macaque homologue of the dorsal medial prefrontal cortex tracks the reliability of social information and determines whether this information is used to guide choices during decision making.

    • Jake Rogers
    Research Highlight
  • Ketamine is ‘trapped’ in the pores of NMDA receptors in the lateral habenula, mediating sustained antidepressant effects in mice.

    • Katherine Whalley
    Research Highlight
  • Grid cells develop in rats soon after they leave the nest. Here, Ulsaker-Janke et al. show that preventing exposure to straight boundaries from birth delays, but does not prevent, grid cell maturation in adult rats.

    • Caroline Barranco
    Research Highlight
  • A new study shows that, in a numerical judgement task, individuals show differences in neuronal coding of numbers below and above approximately four in the medial temporal lobe.

    • Darran Yates
    Research Highlight
  • Architectures in neural networks commonly assume that inference is hierarchical. In this Perspective, Suzuki et al. present the shallow brain hypothesis, a neural processing mechanism based on neuroanatomical and electrophysiological evidence that intertwines hierarchical cortical processing with a massively parallel process to which subcortical areas substantially contribute.

    • Mototaka Suzuki
    • Cyriel M. A. Pennartz
    • Jaan Aru
    Perspective
  • The neuropeptide oxytocin has a vital role in many mammalian social behaviours. Here, Menon and Neumann provide a comprehensive review of the rodent neuronal circuits in which oxytocin acts to regulate the processing of social cues in order to reinforce reproductive and non-reproductive social behaviours.

    • Rohit Menon
    • Inga D. Neumann
    Review Article