Research Highlights in 2010

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  • Germ cells can be directly converted into specific types of neuronin vivo, bypassing the pluripotent stage.

    • Leonie Welberg
    Research Highlight
  • VGLUT2 is a key component of the circuits that mediate the regulation of itching and the suppression of itch by pain.

    • Rachel Jones
    Research Highlight
  • Activation of central TRPV1 receptors by anandamide mediates long-term depression in the hippocampus and nucleus accumbens.

    • Katie Kingwell
    Research Highlight
  • Primary somatosensory cortex can drive motor responses independently of the motor cortex.

    • Leonie Welberg
    Research Highlight
  • The lateral and medial subdivisions of the central amygdala mediate the acquisition and expression of conditioned fear.

    • Leonie Welberg
    Research Highlight
  • CaMKK signalling acts as a cell-autonomous homeostatic regulator of synaptic strength in response to excitation.

    • Rachel Jones
    Research Highlight
  • Normal pacemaking activity in dopamine neurons in the SNc results in high basal mitochondrial oxidative stress levels in these neurons, rendering them vulnerable to degeneration.

    • Leonie Welberg
    Research Highlight
  • The mTORC1 signalling cascade plays a key part in alcohol abuse disorders.

    • Safia Ali Danovi
    Research Highlight
  • Humans can use conscious thought to regulate the activity of MTL neurons encoding different concepts, thereby overriding neuronal activation induced by sensory input.

    • Leonie Welberg
    Research Highlight
  • The SCN drives circadian rhythms in body temperature, which provides the entraining cue for mammalian peripheral clocks.

    • Safia Ali Danovi
    Research Highlight
  • Signalling through the BDNF pathway in the D1 and D2 dopamine receptor expressing neurons in the nucleus accumbens has opposing effects on cocaine reward.

    • Rachel Jones
    Research Highlight
  • Dual specificity protein phosphatase 1 is upregulated in major depressive disorder.

    • Katie Kingwell
    Research Highlight
  • HSV-1 latency is maintained by a host cell signalling pathway activated by NGF.

    • Rachel David
    Research Highlight
  • Endocannabinoid activation of astrocytic CB1Rs potentiates neurotransmission at synapses far away from the site of endocannabinoid release.

    • Leonie Welberg
    Research Highlight
  • The functional integrity of the blood–brain barrier is regulated by pericytes during development and in adulthood.

    • Ezzie Hutchinson
    Research Highlight
  • Defects in the polyamine pathway, including aberrant spermidine/spermine N1-acetyltransferase 1 (SAT1) activity, may play a part in Parkinson's disease pathogenesis.

    • Yukie Ozawa
    Research Highlight
  • SSRIs are used to treat depression and have a delayed onset of action. The mechanism involves post-transcriptional regulation of a serotonin transporter in the raphe nucleus and the locus coeruleus.

    • Sian Lewis
    Research Highlight