Research Highlights

Filter By:

  • The modern human variant of the gene transketolase-like 1, but not the Neanderthal variant, promotes the production of basal radial glia during neocortical development.

    • Darran Yates
    Research Highlight
  • Axo-ciliary synapses that enable rapid signalling to the nucleus are identified in the mouse hippocampus.

    • Katherine Whalley
    Research Highlight
  • Neuromodulation with specific frequencies at specific brain locations selectively enhances either working memory or long-term memory in older adult humans.

    • Jake Rogers
    Research Highlight
  • A study in male mice finds that neurons in the bed nucleus of the stria terminalis shape hypothalamic neural representations to control the transition from appetitive to consummatory innate social behaviour towards conspecifics of both sexes.

    • Jake Rogers
    Research Highlight
  • A new study shows that many olfactory sensory neurons in Aedes aegypti mosquitoes express more than one type of chemosensory receptor and some of these neurons can respond to multiple olfactory cues.

    • Darran Yates
    Research Highlight
  • Combining high-throughput fluorescence-activated cell sorting and single-cell RNA sequencing, neurons with and without neurofibrillary tangles from people with Alzheimer disease were shown to have different molecular signatures.

    • Sian Lewis
    Research Highlight
  • Dynamin mediates vesicle scission during endocytosis, and here is shown to exist with syndapin 1 in biomolecular condensates at the endocytic zone that enable its participation in ultrafast endocytosis.

    • Sian Lewis
    Research Highlight
  • A study in mice finds that different dopamine neuron subsystems in the midbrain track food and fluid ingestion at different stages of this process, and that animals can use this information to learn about the results of ingestion.

    • Darran Yates
    Research Highlight
  • Core features of the language network in the brain are consistent across languages and language families.

    • Jake Rogers
    Research Highlight
  • A subpopulation of GABAergic neurons in the mouse VTA drives restorative sleep in response to social defeat stress.

    • Katherine Whalley
    Research Highlight
  • Dendritic arbors are shaped by adhesion-molecule interactions between developing dendrites and the extracellular environment that are transduced by dendritic mechanosensitive channels into local calcium transients.

    • Sian Lewis
    Research Highlight
  • Brain lesions in individuals who subsequently show remission of smoking addiction share a common connectivity profile.

    • Natasha Bray
    Research Highlight
  • A new study shows that α-synuclein can interact with protein components of membraneless organelles involved in mRNA metabolism, and that such interactions may have relevance in Parkinson disease.

    • Darran Yates
    Research Highlight
  • A population of fever-generating neurons in the hypothalamus coordinates diverse sickness behaviours in mice.

    • Katherine Whalley
    Research Highlight
  • In mice, infusions of young cerebrospinal fluid into the brains of aged animals promote oligodendrogenesis and improve memory.

    • Darran Yates
    Research Highlight
  • A population of spinal interneurons that express prokineticin receptor 2 is needed in mice for the rewarding, antistress and prosocial effects of pleasant touch.

    • Natasha Bray
    Research Highlight
  • Neuronal activity in a key region of the mouse hypothalamus modulates adult hippocampal neurogenesis, promoting the formation of adult-born neurons that support cognition and affective function.

    • Katherine Whalley
    Research Highlight
  • In rodents, absence seizures — a prominent manifestation of generalized epilepsy — drive activity-dependent myelination in the corpus callosum, increase interhemispheric synchrony and drive increases in seizure burden over time.

    • Sian Lewis
    Research Highlight
  • Mice show degradation of their hippocampal place code when they disengage from a virtual goal-directed navigation task.

    • Darran Yates
    Research Highlight