Research Highlights

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  • Ongoing systemic and neurocognitive impairments that continue in a subset of individuals after infection with SARS-CoV-2 infection are found to be associated with reduced serotonin levels.

    • Sian Lewis
    Research Highlight
  • In mice, localized mutant APP expression in the CA3 hippocampal region leads to progressive network dysfunction and hippocampus-dependent memory deficits.

    • Darran Yates
    Research Highlight
  • A new biotinylation-based approach identifies previously unknown cell surface proteins of the axonal initial segment (AIS) and shows a role for contactin-1 in assembly of the AIS extracellular matrix.

    • Lisa Heinke
    Research Highlight
  • The organization and diversity of neuronal and glial primary cilia and their connectivity in the human cortex is characterized in detail.

    • Katherine Whalley
    Research Highlight
  • The macaque homologue of the dorsal medial prefrontal cortex tracks the reliability of social information and determines whether this information is used to guide choices during decision making.

    • Jake Rogers
    Research Highlight
  • Ketamine is ‘trapped’ in the pores of NMDA receptors in the lateral habenula, mediating sustained antidepressant effects in mice.

    • Katherine Whalley
    Research Highlight
  • Grid cells develop in rats soon after they leave the nest. Here, Ulsaker-Janke et al. show that preventing exposure to straight boundaries from birth delays, but does not prevent, grid cell maturation in adult rats.

    • Caroline Barranco
    Research Highlight
  • A new study shows that, in a numerical judgement task, individuals show differences in neuronal coding of numbers below and above approximately four in the medial temporal lobe.

    • Darran Yates
    Research Highlight
  • Following synaptic vesicle exocytosis, synaptotagmin 1 recruits a lipid signalling pathway within the presynaptic plasma membrane that drives local dynamin recruitment and membrane retrieval by endocytosis, thus maintaining membrane homeostasis.

    • Sian Lewis
    Research Highlight
  • A study reports that in the mouse hippocampus, the induction of long-term potentiation is dependent on the structural functions of CaMKII and not its enzymatic activity.

    • Darran Yates
    Research Highlight
  • A juvenile hormone-degrading enzyme localized in the insect equivalent of the blood–brain barrier governs which social role, forager or soldier, worker carpenter ants fulfil.

    • Jake Rogers
    Research Highlight
  • During retinal development in the mouse, angiogenesis was unexpectedly found to depend on temporally restricted dopamine production by retinal ganglion cells, rather than by canonical retinal dopamine neurons.

    • Sian Lewis
    Research Highlight
  • A study identified two different blood biomarker profiles in people hospitalized for COVID-19 that predicted later cognitive deficits.

    • Darran Yates
    Research Highlight
  • Two papers report the development of high performance brain–computer interfaces that can decode speech from cortical activity.

    • Katherine Whalley
    Research Highlight
  • Increasing levels of glial-derived neurotrophic factor using a gene-therapy approach in a macaque model of alcohol use disorder resulted in a lower tendency to relapse into alcohol consumption after a period of abstinence.

    • Sian Lewis
    Research Highlight
  • The stress associated with early-life social deprivation in mice results in corticosterone-driven overstimulation of cortical synapse removal by astrocytes and behavioural abnormalities in mature animals.

    • Sian Lewis
    Research Highlight
  • A new study reveals a neural circuit that regulates innate sexual behaviour in male mice.

    • Darran Yates
    Research Highlight
  • Cardiac disease drives the denervation of the pineal gland, resulting in a loss of neural control of melatonin release and disrupted sleep–wake patterns.

    • Katherine Whalley
    Research Highlight
  • During cortical development, direct neurogenesis was found to generate key glutamatergic projection neuron subclasses and indirect neurogenesis generated and amplified specific subpopulations within these subclasses.

    • Sian Lewis
    Research Highlight