Research Highlights

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  • A mismatch between cell adhesion proteins at the mossy fibre synapse drives female-specific synaptic and cognitive dysfunction in a mouse model of developmental and epileptic encephalopathy 9.

    • Katherine Whalley
    Research Highlight
  • Closure of the critical period of a motor circuit in Drosophila melanogaster larvae is regulated by neuroligin–neurexin signalling between astrocytes and motor neurons.

    • Sian Lewis
    Research Highlight
  • The human hippocampal-entorhinal network supports contextual memory during spatial navigation.

    • Damon Tomlin
    Research Highlight
  • A study shows that reducing tau acetylation protected neurons in a mouse model of traumatic brain injury.

    • Darran Yates
    Research Highlight
  • In humans, the anterior lateral prefrontal cortex is crucial for assessing the likelihood that a future decision will be correct.

    • Damon Tomlin
    Research Highlight
  • Analyses of recurrent neural networks and neural data show how the concept of magnitude is generalized across different contexts.

    • Natasha Bray
    Research Highlight
  • TREM2 acts to limit the progression of amyloid-β-driven tau pathology in a mouse model of Alzheimer disease.

    • Katherine Whalley
    Research Highlight
  • Stressful experience increases erroneous choices in a reward-based learning task by weakening excitatory synapses in the lateral habenula via a reduction in AMPA-receptor-mediated synaptic transmission.

    • Sian Lewis
    Research Highlight
  • A neuroprosthetic baroreflex can restore haemodynamic stability in models of acute and chronic spinal cord injury.

    • Katherine Whalley
    Research Highlight
  • Activity in different parts of the mouse striatum is faithfully predicted by topographically connected areas of cortex.

    • Natasha Bray
    Research Highlight
  • Projections from the anterior cingulate cortex to the nucleus accumbens are required for the social transfer of pain or analgesia in mice.

    • Darran Yates
    Research Highlight
  • In flies, neurons that are common to both sexes regulate aggressive approach, whereas other, sex-specific neurons control attack behaviours.

    • Natasha Bray
    Research Highlight
  • The innate responses of mice to sweet-tasting or bitter-tasting stimuli can be modulated by top-down feedback from the cortex.

    • Katherine Whalley
    Research Highlight
  • A new study provides evidence suggesting that SARS-CoV-2 may be able to enter the CNS via the neural–mucosal interface in the olfactory mucosa.

    • Darran Yates
    Research Highlight
  • Ecotopic expression of three transcription factors induces reprogramming of the DNA methylation pattern of aged or injured retinal ganglion cells to a more ‘youthful’ state.

    • Natasha Bray
    Research Highlight
  • Downward homeostatic regulation of neuronal firing rate in the visual cortex occurs via synaptic scaling and is enabled by sleep.

    • Katherine Whalley
    Research Highlight
  • In marmosets, overactivation of area 25 of the subgenual anterior cingulate cortex alters neural and cardiac activity and behaviour in response to threat.

    • Darran Yates
    Research Highlight
  • Optogenetic stimulation of place cells alters memory-guided spatial navigation in mice, providing evidence for a causal role for these cells in spatial cognition.

    • Katherine Whalley
    Research Highlight
  • Following long-term potentiation, α5-subunit-containing GABA receptors relocalize to inhibitory synapses to amplify inhibition and suppress runaway potentiation.

    • Natasha Bray
    Research Highlight
  • Metabolites regulated by the microbiota of pregnant mice modulates the developing embryonic brain and influences thalamocortical axon formation and subsequent sensorimotor behaviour in adult offspring.

    • Sian Lewis
    Research Highlight