Research Highlights

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  • Dynamin mediates vesicle scission during endocytosis, and here is shown to exist with syndapin 1 in biomolecular condensates at the endocytic zone that enable its participation in ultrafast endocytosis.

    • Sian Lewis
    Research Highlight
  • A study in mice finds that different dopamine neuron subsystems in the midbrain track food and fluid ingestion at different stages of this process, and that animals can use this information to learn about the results of ingestion.

    • Darran Yates
    Research Highlight
  • Core features of the language network in the brain are consistent across languages and language families.

    • Jake Rogers
    Research Highlight
  • A subpopulation of GABAergic neurons in the mouse VTA drives restorative sleep in response to social defeat stress.

    • Katherine Whalley
    Research Highlight
  • Dendritic arbors are shaped by adhesion-molecule interactions between developing dendrites and the extracellular environment that are transduced by dendritic mechanosensitive channels into local calcium transients.

    • Sian Lewis
    Research Highlight
  • Brain lesions in individuals who subsequently show remission of smoking addiction share a common connectivity profile.

    • Natasha Bray
    Research Highlight
  • A new study shows that α-synuclein can interact with protein components of membraneless organelles involved in mRNA metabolism, and that such interactions may have relevance in Parkinson disease.

    • Darran Yates
    Research Highlight
  • A population of fever-generating neurons in the hypothalamus coordinates diverse sickness behaviours in mice.

    • Katherine Whalley
    Research Highlight
  • In mice, infusions of young cerebrospinal fluid into the brains of aged animals promote oligodendrogenesis and improve memory.

    • Darran Yates
    Research Highlight
  • A population of spinal interneurons that express prokineticin receptor 2 is needed in mice for the rewarding, antistress and prosocial effects of pleasant touch.

    • Natasha Bray
    Research Highlight
  • Neuronal activity in a key region of the mouse hypothalamus modulates adult hippocampal neurogenesis, promoting the formation of adult-born neurons that support cognition and affective function.

    • Katherine Whalley
    Research Highlight
  • In rodents, absence seizures — a prominent manifestation of generalized epilepsy — drive activity-dependent myelination in the corpus callosum, increase interhemispheric synchrony and drive increases in seizure burden over time.

    • Sian Lewis
    Research Highlight
  • Mice show degradation of their hippocampal place code when they disengage from a virtual goal-directed navigation task.

    • Darran Yates
    Research Highlight
  • Food craving-like behaviours in pregnant mice are associated with changes in dopamine signalling.

    • Natasha Bray
    Research Highlight
  • Two papers explore cortical contributions to the evaluation of social rank in mice.

    • Katherine Whalley
    Research Highlight
  • Bright light exerts antinociceptive effects in mice by activating a visual circuit involving the periaqueductal grey.

    • Darran Yates
    Research Highlight
  • The rapid switch from movement planning to execution is mediated by midbrain neurons that transmit information to cortex via the thalamus.

    • Sian Lewis
    Research Highlight
  • Two studies identify a mechanism linking TDP-43 pathology with genetic variants associated with increased risk of neurodegenerative disorders.

    • Natasha Bray
    Research Highlight
  • Hyperexcitability of a population of arousal-promoting neurons in the hypothalamus drives sleep instability in aged mice.

    • Katherine Whalley
    Research Highlight
  • A small population of neurons coordinates spontaneous activity and regulates synapse formation in the developing fly brain.

    • Katherine Whalley
    Research Highlight