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The idea that learned associations are encoded within neuronal ensembles has so far mainly been based on correlational data. This Progress article describes recently developed approaches that can selectively target and study activated neuronal ensembles in models of addiction and relapse and in conditioned fear.
Recent studies have shown that the protein p11 (also known as S100A10) has an important role in depression-like behaviour and antidepressant actions. Greengard and colleagues discuss the molecular and cellular mechanisms that may underlie this role.
