Articles in 2022

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  • Prioritization of visual inputs manifests itself in different behavioural signatures. In this Review, Rust and Cohen describe these signatures and their neural correlates and suggest that the brain uses a unified priority signal from which downstream areas can decode different types of priority.

    • Nicole C. Rust
    • Marlene R. Cohen
    Review Article
  • The past two decades have witnessed considerable interest in linking interindividual differences in behaviour to differences in brain structure. In this Perspective, Genon et al. examine how the study of brain structure–behaviour associations in healthy populations has developed during this period and the current challenges for this field.

    • Sarah Genon
    • Simon B. Eickhoff
    • Shahrzad Kharabian
    Perspective
  • Bright light exerts antinociceptive effects in mice by activating a visual circuit involving the periaqueductal grey.

    • Darran Yates
    Research Highlight
  • People may respond to listening to music by physically moving or feeling emotions. In this Review, Peter Vuust and colleagues discuss how music perception and related actions, emotions and learning are associated with the predictive capabilities of the human brain, with a focus on their predictive coding of music model.

    • Peter Vuust
    • Ole A. Heggli
    • Morten L. Kringelbach
    Review Article
  • The rapid switch from movement planning to execution is mediated by midbrain neurons that transmit information to cortex via the thalamus.

    • Sian Lewis
    Research Highlight
  • Two studies identify a mechanism linking TDP-43 pathology with genetic variants associated with increased risk of neurodegenerative disorders.

    • Natasha Bray
    Research Highlight
  • Hyperexcitability of a population of arousal-promoting neurons in the hypothalamus drives sleep instability in aged mice.

    • Katherine Whalley
    Research Highlight
  • There is a dichotomy in human neuroscience research between task-based cognition and characterization of intrinsic neural patterns (for example, resting-state networks), In this Review, Liu and colleagues discuss a new paradigm for bridging this gap based on decoding of task-related representations.

    • Yunzhe Liu
    • Matthew M. Nour
    • Raymond J. Dolan
    Review Article
  • Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting both upper and lower motor neurons. Various genes have been linked to ALS, leading to the generation of many rodent models of this disease. In this Review, Todd and Petrucelli provide a broad overview of these models.

    • Tiffany W. Todd
    • Leonard Petrucelli
    Review Article
  • Impaired insulin signalling is now established as a key component of Alzheimer disease (AD) pathology. In this review, De Felice and colleagues discuss the contribution of impaired insulin signalling and allostatic load in AD and highlight the potential of social and lifestyle interventions to preserve brain health and ward off AD.

    • Fernanda G. De Felice
    • Rafaella A. Gonçalves
    • Sergio T. Ferreira
    Review Article
  • Local activation of presynaptic receptors alters neurotransmitter release, modulating effects of somatic action potentials. In this Review, Lovinger et al. discuss the role of presynaptic receptors in regulating synaptic transmission and directions for future research aimed at determining the in vivo roles of presynaptic receptors.

    • David M. Lovinger
    • Yolanda Mateo
    • Joseph F. Cheer
    Review Article
  • A small population of neurons coordinates spontaneous activity and regulates synapse formation in the developing fly brain.

    • Katherine Whalley
    Research Highlight
  • Immune genes implicated in multiple sclerosis pathology are shown to be primed but not expressed in oligodendrocyte precursor cells in both mouse and human.

    • Sian Lewis
    Research Highlight
  • Neuropeptide Y released in the rat spleen by neurons of the suprarenal and coeliac ganglia can regulate immune-cell activation.

    • Natasha Bray
    Research Highlight
  • Androgen signalling during development may represent the mechanism underpinning some observed sex-differences in adult human brain size.

    • Jake Rogers
    Research Highlight