Articles in 2018

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  • Dopamine released in the rodent prefrontal cortex increases the signal-to-noise ratio of responses to aversive stimuli that are transmitted to the periaqueductal grey.

    • Natasha Bray
    Research Highlight
  • Necroptosis is a form of cell death mediated by receptor-interacting protein kinase 1 (RIPK1), and is observed in several CNS disorders. Here, Yuan, Amin and Ofengeim give an overview of necroptosis in the CNS and explain its relationship with inflammation in CNS disorders.

    • Junying Yuan
    • Palak Amin
    • Dimitry Ofengeim
    Review Article
  • Neural stem and progenitor cells can be regulated through mitochondrial signalling mechanisms and this has major implications in physiological and pathological conditions. In this Review, Khacho and colleagues discuss how mitochondria can serve as signalling organelles that modify the fate of stem cells in the brain.

    • Mireille Khacho
    • Richard Harris
    • Ruth S. Slack
    Review Article
  • Many neurobiological processes are regulated on a circadian basis. Circadian rhythms change during development, into adulthood and with ageing, when certain disorders typically emerge. Here, Logan and McClung give an overview of the relationship between the circadian system and brain disorders across various life stages.

    • Ryan W. Logan
    • Colleen A. McClung
    Review Article
  • A study shows that during brain development in mice, CD47 prevents excessive synaptic pruning by microglia.

    • Darran Yates
    Research Highlight
  • Astrocytes display widespread functional diversity that translates into distinct regulation of synaptic circuits. In this Review, Dallérac and colleagues discuss the determinants of these divergent regulations throughout life focusing on astroglial intrinsic heterogeneity, developmental changes and activity-dependent processes.

    • Glenn Dallérac
    • Jonathan Zapata
    • Nathalie Rouach
    Review Article
  • Animals may adopt an active-sampling strategy to assess their environment. In this Review, Jacqueline Gottlieb and Pierre-Yves Oudeyer explore the emerging neuroscientific literature examining active sampling and how it relates to attention and curiosity.

    • Jacqueline Gottlieb
    • Pierre-Yves Oudeyer
    Review Article
  • A population of spinal excitatory interneurons can be targeted for the maintenance of respiratory function after spinal cord injury in mice.

    • Katherine Whalley
    Research Highlight
  • Dendritic mitochondria in stimulated neurons undergo fission that is required for long-term potentiation.

    • Natasha Bray
    Research Highlight
  • Traditionally, the CNS is described to have immune privilege, largely because of its immunological barriers. Here, Forrester, McMenamin and Dando describe how this immune privilege may sometimes not be beneficial, as it enables invading pathogens to exist as latent CNS infections.

    • John V. Forrester
    • Paul G. McMenamin
    • Samantha J. Dando
    Review Article
  • Age-related changes in cognitive ability are the focus of a growing field of research. Cabeza, Rajah and colleagues aim to promote clarity in the field by agreeing upon consensual definitions for three widely discussed concepts: maintenance, compensation and reserve.

    • Roberto Cabeza
    • Marilyn Albert
    • M. Natasha Rajah
  • A new study finds that, in mice, location-related signals affect activity in the primary visual cortex.

    • Darran Yates
    Research Highlight
  • Recent research advances have yielded fresh insights into the fundamental neural processes underlying pair bonding. In this Review, Walum and Young discuss how neural representations of a partner become inherently rewarding, providing intriguing insights into the neural origins of love.

    • Hasse Walum
    • Larry J. Young
    Review Article