Articles in 2017

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  • Activity-driven changes in gene transcription regulate synaptic development and function. Bading and colleagues describe recent evidence of lineage-specific changes in the gene regulatory regions that govern excitation–transcription coupling and consider how such changes may have contributed to the evolution of human cognitive abilities.

    • Giles E. Hardingham
    • Priit Pruunsild
    • Hilmar Bading
  • 'Silent' synapses enable motion detection by retinal direction-selective ganglion cells at near-threshold contrasts.

    • Natasha Bray
    Research Highlight
  • The dopamine motive system, which integrates reinforcement and motivation, is influenced by obesogenic foods and addictive drugs. In this Review, Volkow and colleagues highlight how these stimuli sensitize the subject's motivation towards them while desensitizing the subject's motivation towards alternative reinforcers.

    • Nora D. Volkow
    • Roy A. Wise
    • Ruben Baler
    Review Article
  • Promoting remyelination may be an effective therapeutic strategy for various disorders that are characterized by a loss of myelin, including multiple sclerosis. In this Review, Franklin and ffrench-Constant discuss recent developments in our understanding of remyelination and the efforts that are underway to enhance this process.

    • Robin J. M. Franklin
    • Charles ffrench-Constant
    Review Article
  • In fear conditioning in mice, neurons in the lateral central amygdala that express protein kinase Cδ convey the unconditioned stimulus to the lateral amygdala to enable the encoding of aversive memory.

    • Natasha Bray
    Research Highlight
  • Methylation of neuronal genes at CA sequences is modulated by neuronal activity during early postnatal periods and fine tunes gene expression in adult neurons.

    • Katherine Whalley
    Research Highlight
  • Spatial position is spontaneously stored as part of working memory, even in tasks where spatial location is not relevant to the task.

    • Sian Lewis
    Research Highlight
  • In a working memory task, the neural code for the target stimulus in the lateral prefrontal cortex transforms when a distractor is presented, without loss of target-related information.

    • Natasha Bray
    Research Highlight
  • In recent years, several funding agencies have introduced requirements for researchers to consider sex as a biological variable in preclinical research. In this Comment article, McCarthy and colleagues discuss the potential impact of these policies for neuroscience research.

    • Margaret M. McCarthy
    • Catherine S. Woolley
    • Arthur P. Arnold
  • An axon's function is dictated by its morphology and, thus, by the properties and organization of the axonal cytoskeleton. Leterrieret al. describe how advances in super-resolution and live-cell imaging are transforming our understanding of the molecular architecture of the axonal shaft.

    • Christophe Leterrier
    • Pankaj Dubey
    • Subhojit Roy
    Review Article
  • A causal explanation for the pathogenesis of schizophrenia is lacking. In this Review, Birnbaum and Weinberger explore recent genetic studies of schizophrenia and discuss how genetic and epigenetic risk of the disorder may converge to perturb key neurodevelopmental trajectories.

    • Rebecca Birnbaum
    • Daniel R. Weinberger
    Review Article
  • Apolipoprotein E4 promotes tau neurotoxicity in a mouse model of tau-mediated neurodegenerative disease.

    • Darran Yates
    Research Highlight