Articles in 2012

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  • Hippocampal fast excitatory synapses exhibit both full collapse fusion and 'kiss and run'. Parket al. show that the type of fusion a vesicle will undergo depends on the location and the time spent at the active zone prior to fusion.

    • Sian Lewis
    Research Highlight
  • In mice, sound-induced activation of the primary auditory cortex can inhibit activity in the primary visual cortex and affect visual stimulus-induced behaviour.

    • Darran Yates
    Research Highlight
  • A growing field of research aims to examine the potential overlap between the characteristics and underlying mechanisms of drug addiction and obesity. Here, Fletcher and colleagues argue that there is not yet sufficient evidence to support a 'food addiction' model and call for caution in the application of this model to clinical and policy recommendations.

    • Hisham Ziauddeen
    • I. Sadaf Farooqi
    • Paul C. Fletcher
    Opinion
  • The microRNA miR-34 and the transcription factor E74A are involved in adult-onset neurodegeneration inDrosophila melanogaster.

    • Man Tsuey Tse
    Research Highlight
  • Normal ageing is associated with impairments in cognitive function, including memory, and with specific and relatively subtle synaptic alterations in the hippocampus and prefrontal cortex. The authors describe these structural changes reported in monkeys and rodents, how they might affect age-associated cognitive decline and potential strategies to limit their impact.

    • John H. Morrison
    • Mark G. Baxter
    Review Article
  • Dysfunction of the circadian clock contributes to the age-associated decline of brain functions. Here, the authors examine the evidence for this link and the potential underlying molecular mechanisms such as the circadian control of brain metabolism and hormone secretion.

    • Anna A. Kondratova
    • Roman V. Kondratov
    Review Article
  • The primary cilium regulates the integration of adult-born dentate granule cells into functional circuits.

    • Monica Hoyos Flight
    Research Highlight
  • In the amygdala, oxytocin release from long-range hypothalamic axonal projections reduces fear responses.

    • Darran Yates
    Research Highlight
  • Hypothermia has neuroprotective effects in certain clinical conditions and in animal models of brain insult. Yenari and Han review the mechanisms that underlie these effects. Focusing on animal models of ischaemia, they describe how cooling influences multiple aspects of brain physiology in the acute, subacute and chronic stages of ischaemia.

    • Midori A. Yenari
    • Hyung Soo Han
    Review Article
  • In recent decades, advances in technology have enabled the structure of the nervous system to be dissected in greater detail than ever before. In this Opinion article, Denk and colleagues outline why structural information is so important for our understanding of the function of neural circuits and describe new tools and approaches that are improving the structural information that we can acquire.

    • Winfried Denk
    • Kevin L. Briggman
    • Moritz Helmstaedter
    Opinion