Articles in 2010

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  • Inhibitors of leucinerich repeat kinase 2 reduce neuronal damage in a mouse model of Parkinson's disease.

    • Katie Kingwell
    Research Highlight
  • Toll-like receptor 3 signalling suppresses hippocampal neurogenesis and impairs working memory.

    • Ezzie Hutchinson
    Research Highlight
  • Glucocorticoid hormones modulate the acquisition and consolidation of memories of stressful events. Krugers and colleagues review recent evidence that glucocorticoids achieve this through rapid and persistent effects on AMPA receptors by activation of mineralocorticoid receptors and glucocorticoid receptors, respectively.

    • Harmen J. Krugers
    • Casper C. Hoogenraad
    • Laurent Groc
    Progress
  • Emotional stimuli, such as a fear-expressing face, can be processed without being consciously perceived and can influence behaviour. Tamietto and de Gelder describe the subcortical pathway that processes such stimuli, and discuss whether subcortical versus cortical processing of stimuli translate into non-conscious versus conscious perception. An interview with Beatrice de Gelder for Neuropod is available for download.

    • Marco Tamietto
    • Beatrice de Gelder
    Review Article
  • tau regulates the interaction of postsynaptic density protein 95 (PSD95) with NMDA (N-methyl-D-aspartate) receptors, which are thought to mediate Aβ toxicity.

    • Claudia Wiedemann
    Research Highlight
  • translational regulation of E2F1 and DP by miRNAs is implicated in LRRK2-mediated pathogenesis in Parkinson's disease.

    • Claudia Wiedemann
    Research Highlight
  • Astrocytes control breathing through pH-dependent release of ATP.

    • Leonie Welberg
    Research Highlight
  • SIRT1 modulates synaptic plasticity through microRNA-dependent regulation of the transcription factor cAMP-responsive element-binding (CREB) protein.

    • Claudia Wiedemann
    Research Highlight
  • Socioeconomic status (SES) influences brain development. Farah and colleagues discuss evidence that prenatal factors, parent–child interactions and cognitive stimulation mediate this effect, and consider implications for alleviating SES-related disparities in mental health and academic achievement.

    • Daniel A. Hackman
    • Martha J. Farah
    • Michael J. Meaney
    Science and Society
  • In this Perspective, Vollenweider and Kometer discuss the clinical potential of psychedelic drugs for the treatment of various psychiatric disorders, and describe the molecular mechanisms by which classical hallucinogens and dissociative anaesthetics affect serotonin and glutamate systems. An interview with Franz X. Vollenweider for Neuropod is available for download.

    • Franz X. Vollenweider
    • Michael Kometer
    Opinion
  • New neurons control, through Slit-Robo signalling, the organization of the glial tubes through which they migrate in the RMS.

    • Leonie Welberg
    Research Highlight
  • Signalling by metabotropic glutamate receptor 4 counteracts neuroinflammation in a rodent model of multiple sclerosis.

    • Katie Kingwell
    Research Highlight