Articles in 2010

Hedgehog signalling establishes spatial correspondence between olfactory receptor neurons and their targets in the brain through a two-step mechanism.

The extracellular matrix (ECM) plays a key part in diverse cellular processes. Dityatev and colleagues review how the ECM can have opposing effects on neuronal function — promoting plasticity or homeostasis of synaptic contacts — depending on the physiological context and regulation by key proteases.

In this Review, Redgraveet al. provide an updated model of basal ganglia architecture in which spatially segregated functional territories contribute to goal-directed and habitual control circuits. They propose that in Parkinson's disease, selective dopamine loss impairs habitual control and distorts goal-directed behaviours.

Regional variations in aerobic glycolysis in young adults correlate spatially with amyloid-β deposition in older individuals.

DISC1 negatively regulates synaptic strength by inhibiting the TNIK-dependent stabilization of postsynaptic proteins.

EGFR–Notch 1 pathway interactions balance neural stem cell and progenitor cell populations.

Glutamate can facilitate inhibitory glycine receptor signalling in the spinal cord and brainstem through allosteric modulation.

To celebrate the first 10 years ofNature Reviews Neuroscience, we invited the authors of the most cited article of each year to look back on the state of their field at the time of publication and the impact their article has had, and to discuss the questions that might be answered in the next 10 years.

Presynaptic GABA_Breceptors sense local variations in basal GABA levels and homeostatically regulate release probability at individual excitatory boutons.

Glia can discriminate patterns of synaptic activity and modulate synaptic plasticity through balanced A₁ and A₂adenosine receptor activation.

Transient receptor potential cation channel N1 is a mechanosensitive channel in fruitflies and nematode worms.

Exercise reduces food intake through an interleukin-6 (IL-6)-mediated mechanism acting in the hypothalamus.

NR1/NR3-containing 'NMDA' receptors are expressedin vivoin myelin and can be activated by glycine alone

regulation of MeCP2 by drugs of abuse contributes to behavioural and neural responses to the drugs

Lightman and Conway-Campbell review findings showing that, superimposed on its well-known circadian rhythm, the HPA axis shows ultradian, oscillatory activity. They describe how the resulting pulsatile release of glucocorticoids maintains optimal responsiveness of the HPA axis and the brain processes regulated by these hormones.