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  • Battaglia and colleagues discuss evidence for functional interactions between memory replay and default mode network (DMN) activity and propose an updated model of memory consolidation and retrieval in which the DMN acts as a hub for cascaded replay across the brain.

    • Karola Kaefer
    • Federico Stella
    • Francesco P. Battaglia
    Perspective
  • Dynamin mediates vesicle scission during endocytosis, and here is shown to exist with syndapin 1 in biomolecular condensates at the endocytic zone that enable its participation in ultrafast endocytosis.

    • Sian Lewis
    Research Highlight
  • A study in mice finds that different dopamine neuron subsystems in the midbrain track food and fluid ingestion at different stages of this process, and that animals can use this information to learn about the results of ingestion.

    • Darran Yates
    Research Highlight
  • Core features of the language network in the brain are consistent across languages and language families.

    • Jake Rogers
    Research Highlight
  • High-resolution transcriptomic studies have enabled detailed dissection of the diverse cell types of the hypothalamus in adulthood and at different stages of development. In this Review, Benevento, Hökfelt and Harkany describe the processes that govern the generation and specification of cell types in the developing hypothalamus.

    • Marco Benevento
    • Tomas Hökfelt
    • Tibor Harkany
    Review Article
  • A subpopulation of GABAergic neurons in the mouse VTA drives restorative sleep in response to social defeat stress.

    • Katherine Whalley
    Research Highlight
  • In this Review, Liu and Bohórquez explore the neural basis for sugar preference in mammals. The authors discuss the role of the gut in recognizing glucose and its consequence for sugar preference.

    • Winston W. Liu
    • Diego V. Bohórquez
    Review Article
  • Recent studies of transient receptor potential (TRP) channel structure have provided unique insight into the function of TRP channels in our normal sensations and in pain. In this Review, Rosenbaum et al. examine recent advances in the field of TRP ion channel structure–function relationships and their role in pain.

    • Tamara Rosenbaum
    • Sara L. Morales-Lázaro
    • León D. Islas
    Review Article
  • Social valence — the valence assigned to a social agent or social stimulus — is complex to compute. In this Review, Padilla-Coreano et al. explain how social attributes, social history, social memory, social rank and social isolation states are integrated to modulate social valence assignment.

    • Nancy Padilla-Coreano
    • Kay M. Tye
    • Moriel Zelikowsky
    Review Article
  • Dendritic arbors are shaped by adhesion-molecule interactions between developing dendrites and the extracellular environment that are transduced by dendritic mechanosensitive channels into local calcium transients.

    • Sian Lewis
    Research Highlight
  • Brain lesions in individuals who subsequently show remission of smoking addiction share a common connectivity profile.

    • Natasha Bray
    Research Highlight
  • A new study shows that α-synuclein can interact with protein components of membraneless organelles involved in mRNA metabolism, and that such interactions may have relevance in Parkinson disease.

    • Darran Yates
    Research Highlight
  • What’s the point of public engagement? Why can’t we just be neuroscience researchers? In this Comment I will argue that communicating our science is a key aspect of being a neuroscientist and that our science can be enriched by this.

    • Sophie K. Scott
    Comment
  • When anticipating a threat, many animals ‘freeze’, becoming temporarily immobile. Roelofs and Dayan argue that this response enables the coordination of cognitive and somatic processes that prepare the animal for action and describe how CNS, autonomic and sensorimotor activity must be integrated to regulate freezing.

    • Karin Roelofs
    • Peter Dayan
    Perspective
  • A population of fever-generating neurons in the hypothalamus coordinates diverse sickness behaviours in mice.

    • Katherine Whalley
    Research Highlight
  • In this Review, Panzeri, Moroni, Safaai and Harvey explain how the levels and structures of correlations among the activity of neurons in a population shape information encoding, transmission and readout, and describe how future research could determine how the structures of correlations are optimized.

    • Stefano Panzeri
    • Monica Moroni
    • Christopher D. Harvey
    Review Article
  • In mice, infusions of young cerebrospinal fluid into the brains of aged animals promote oligodendrogenesis and improve memory.

    • Darran Yates
    Research Highlight
  • Comparisons of real networks with null models enable researchers to test how statistically unexpected a particular network feature is. In this Review, Váša and Mišić describe different null-model approaches and instantiations, as well as their emerging uses and limitations.

    • František Váša
    • Bratislav Mišić
    Review Article
  • Hippocampal inhibitory interneurons shape memory formation and storage through cell type-specific mechanisms. In this review, Topolnik and Tamboli discuss how soma-targeting, dendrite-targeting and interneuron-targeting interneurons may specialize in supporting hippocampal oscillations, synaptic plasticity and memory processes.

    • Lisa Topolnik
    • Suhel Tamboli
    Review Article