Browse Articles

Philip Tovote describes the 1980 paper in which Michael Fanselow systematically investigated freezing as a defensive response in rodents

Activation of nociceptor neurons expressing TRPV1 downregulates gut regulatory T cells.

Most astrocytes in the mouse brain have a primary cilium that transduces local cues to drive distinct astrocytic transcriptomic programmes that determine regional astrocytic subtypes, and, in turn, shape local circuits and influence behaviour.

A study in humans reveals that the hippocampus encodes relevant task variables in abstract format during inferential reasoning, which enables the generalization needed for such complex cognition.

Study identifies 'predictive grid cells' in the rat entorhinal cortex that encode projected future locations.

Thyroid hormone induces cortical circuit plasticity to modulate exploratory behaviours in mice.

An array of genetically encoded tools are now available to label and manipulate synapses in different experimental species. Kaang and colleagues provide an overview of these techniques, highlighting their advantages, disadvantages and utility for investigating synaptic function.

During their maturation, mammalian neurons lose the capacity to regrow their axons after an injury. Here, Hilton et al. explore the neuron maturation processes that limit axon regeneration, including changes in gene expression, cytoskeletal dynamics, and intracellular signalling and trafficking.

How the complex functionality of the human brain depends on its underlying white matter architecture is incompletely understood. In this Review, Fotiadis et al. synthesize the heterogeneous macroscale expression of normative structure–function coupling and then discuss how it is affected in neurological and psychiatric conditions.

A study finds that microglia depletion has no effect on experience-dependent maturation of visual cortex circuitry in mice.

How the brain routinely processes information from different sensory modalities during everyday tasks is not well understood. In this Perspective, Engel and Senkowski propose how oscillatory neural mechanisms operating at multiple timescales within and across brain networks can mediate such multisensory integration.

Longitudinal precision functional mapping reveals that acute desynchronization of functional connectivity organization induced by the psychedelic psilocybin can persist long-term in the human brain.

Two studies use large-scale genome sequencing data to identify variants in a noncoding gene that cause a neurodevelopmental syndrome in many individuals.

Cerebellar Purkinje neurons modulate thirst in mice

In recent years, genomic studies have identified numerous genetic variants as risk factors for schizophrenia. Sullivan et al. describe our current understanding of the complex genetic architecture of schizophrenia and consider how the genomic findings can be interrogated to boost our understanding of the neurobiology of the disorder.

Acid-sensing ion channel 3 in nociceptors exacerbates inflammation in psoriasis by inducing the release of calcitonin gene-related peptide from these neurons.

A new modelling method developed in male Drosophila melanogaster maps how populations of neurons transform visual stimuli into courtship behaviours without recording neural activity.