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  • Schemas are structured bodies of prior knowledge that reflect common patterns of information from related experiences. In this Review, Farzanfar et al. discuss evidence for spatial schemas, how they form and how they differ from cognitive maps.

    • Delaram Farzanfar
    • Hugo J. Spiers
    • R. Shayna Rosenbaum
    Review Article
  • A gut–brain circuit that mediates retching and nausea in response to enterotoxins and chemotheraputic drugs is characterized in mice.

    • Katherine Whalley
    Research Highlight
  • The molecular organization of the synapse is both highly organized and dynamic. Triller and colleagues outline advances in single-particle tracking technologies that have enabled us to gain quantitative insights into the mechanisms that regulate postsynaptic receptor dynamics.

    • Stephanie A. Maynard
    • Jonas Ranft
    • Antoine Triller
    Review Article
  • When humans attempt two tasks at once, there are costs to task performance. In this Perspective, Garner and Dux discuss neurophysiological evidence for whether these multitasking costs are linked to the human capability for rapid knowledge generalization to perform novel tasks.

    • Kelly G. Garner
    • Paul E. Dux
    Perspective
  • Attractor network dynamics can support several computations performed by the brain. In their Review, Khona and Fiete introduce different attractor dynamics and their computational utility, describe evidence of attractor networks across the brain and explain how such networks could be recombined to increase their flexibility and versatility.

    • Mikail Khona
    • Ila R. Fiete
    Review Article
  • In mice, a neurodegenerative pathway involving Tbk1 gene mutations and chromosome 9 open reading frame 72 repeat expansions impairs endosome maturation and induces cytoplasmic TBP-43 aggregation.

    • Jake Rogers
    Research Highlight
  • Barosensitive neurons in the medullary nucleus of the solitary tract can decrease wakefulness and increase non-REM sleep in mice through the same circuitry that regulates cardiovascular function.

    • Jake Rogers
    Research Highlight
  • There is increasing evidence that neurons are not the only cells affected by and contributing to neurodegenerative disorders. In this Review, Brandebura and colleagues discuss the role astrocytes play in neurodegenerative disorders as initiators of and contributors to disease progression.

    • Ashley N. Brandebura
    • Adrien Paumier
    • Nicola J. Allen
    Review Article
  • Understanding how brain circuits have been altered by evolution can provide insight into their development and function. Prieto-Godino and colleagues provide an overview of our current understanding of the principles of central circuit evolution, drawing on numerous examples from across the animal kingdom.

    • Ruairí J. V. Roberts
    • Sinziana Pop
    • Lucia L. Prieto-Godino
    Review Article
  • Preventing transient defects in postnatal cortical circuit function limits disease progression in a mouse model of Huntington disease.

    • Katherine Whalley
    Research Highlight
  • Fluorescent sensors of molecular activity have revolutionized our knowledge of the brain. However, their signals report a reaction between the target and the sensor molecules rather than the activity of interest per se. Thus, understanding the location, sensitivity and imaging environment of a sensor should help to avoid misinterpretation of its readout.

    • Dmitri A. Rusakov
    Comment
  • Modern approaches for multiregion investigation provide new opportunities and considerations for exploring brainwide neural dynamics. In this Review, Machado, Kauvar and Deisseroth discuss advances in the simultaneous measurement and analysis of neuronal activity across many brain regions.

    • Timothy A. Machado
    • Isaac V. Kauvar
    • Karl Deisseroth
    Review Article
  • The progenitor cell populations that establish the developing human cortex exhibit distinct forms of apical–basal polarity. Kriegstein and colleagues review the mechanisms that regulate human cortical progenitor polarity, its importance for cortical development and the consequences of its disruption in neurological disorders.

    • Madeline G. Andrews
    • Lakshmi Subramanian
    • Arnold R. Kriegstein
    Review Article