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  • Axo-ciliary synapses that enable rapid signalling to the nucleus are identified in the mouse hippocampus.

    • Katherine Whalley
    Research Highlight
  • Neuromodulation with specific frequencies at specific brain locations selectively enhances either working memory or long-term memory in older adult humans.

    • Jake Rogers
    Research Highlight
  • One major form of timing is the estimation of duration. In this Review, Tsao et al. describe the neural bases for estimating ongoing durations and those for estimating durations between past events within memory.

    • Albert Tsao
    • S. Aryana Yousefzadeh
    • Edvard I. Moser
    Review Article
  • A study in male mice finds that neurons in the bed nucleus of the stria terminalis shape hypothalamic neural representations to control the transition from appetitive to consummatory innate social behaviour towards conspecifics of both sexes.

    • Jake Rogers
    Research Highlight
  • A new study shows that many olfactory sensory neurons in Aedes aegypti mosquitoes express more than one type of chemosensory receptor and some of these neurons can respond to multiple olfactory cues.

    • Darran Yates
    Research Highlight
  • Combining high-throughput fluorescence-activated cell sorting and single-cell RNA sequencing, neurons with and without neurofibrillary tangles from people with Alzheimer disease were shown to have different molecular signatures.

    • Sian Lewis
    Research Highlight
  • Battaglia and colleagues discuss evidence for functional interactions between memory replay and default mode network (DMN) activity and propose an updated model of memory consolidation and retrieval in which the DMN acts as a hub for cascaded replay across the brain.

    • Karola Kaefer
    • Federico Stella
    • Francesco P. Battaglia
    Perspective
  • Dynamin mediates vesicle scission during endocytosis, and here is shown to exist with syndapin 1 in biomolecular condensates at the endocytic zone that enable its participation in ultrafast endocytosis.

    • Sian Lewis
    Research Highlight
  • A study in mice finds that different dopamine neuron subsystems in the midbrain track food and fluid ingestion at different stages of this process, and that animals can use this information to learn about the results of ingestion.

    • Darran Yates
    Research Highlight
  • Core features of the language network in the brain are consistent across languages and language families.

    • Jake Rogers
    Research Highlight
  • High-resolution transcriptomic studies have enabled detailed dissection of the diverse cell types of the hypothalamus in adulthood and at different stages of development. In this Review, Benevento, Hökfelt and Harkany describe the processes that govern the generation and specification of cell types in the developing hypothalamus.

    • Marco Benevento
    • Tomas Hökfelt
    • Tibor Harkany
    Review Article
  • A subpopulation of GABAergic neurons in the mouse VTA drives restorative sleep in response to social defeat stress.

    • Katherine Whalley
    Research Highlight
  • In this Review, Liu and Bohórquez explore the neural basis for sugar preference in mammals. The authors discuss the role of the gut in recognizing glucose and its consequence for sugar preference.

    • Winston W. Liu
    • Diego V. Bohórquez
    Review Article
  • Recent studies of transient receptor potential (TRP) channel structure have provided unique insight into the function of TRP channels in our normal sensations and in pain. In this Review, Rosenbaum et al. examine recent advances in the field of TRP ion channel structure–function relationships and their role in pain.

    • Tamara Rosenbaum
    • Sara L. Morales-Lázaro
    • León D. Islas
    Review Article
  • Social valence — the valence assigned to a social agent or social stimulus — is complex to compute. In this Review, Padilla-Coreano et al. explain how social attributes, social history, social memory, social rank and social isolation states are integrated to modulate social valence assignment.

    • Nancy Padilla-Coreano
    • Kay M. Tye
    • Moriel Zelikowsky
    Review Article
  • Dendritic arbors are shaped by adhesion-molecule interactions between developing dendrites and the extracellular environment that are transduced by dendritic mechanosensitive channels into local calcium transients.

    • Sian Lewis
    Research Highlight