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  • What’s the point of public engagement? Why can’t we just be neuroscience researchers? In this Comment I will argue that communicating our science is a key aspect of being a neuroscientist and that our science can be enriched by this.

    • Sophie K. Scott
    Comment
  • When anticipating a threat, many animals ‘freeze’, becoming temporarily immobile. Roelofs and Dayan argue that this response enables the coordination of cognitive and somatic processes that prepare the animal for action and describe how CNS, autonomic and sensorimotor activity must be integrated to regulate freezing.

    • Karin Roelofs
    • Peter Dayan
    Perspective
  • A population of fever-generating neurons in the hypothalamus coordinates diverse sickness behaviours in mice.

    • Katherine Whalley
    Research Highlight
  • In this Review, Panzeri, Moroni, Safaai and Harvey explain how the levels and structures of correlations among the activity of neurons in a population shape information encoding, transmission and readout, and describe how future research could determine how the structures of correlations are optimized.

    • Stefano Panzeri
    • Monica Moroni
    • Christopher D. Harvey
    Review Article
  • In mice, infusions of young cerebrospinal fluid into the brains of aged animals promote oligodendrogenesis and improve memory.

    • Darran Yates
    Research Highlight
  • Comparisons of real networks with null models enable researchers to test how statistically unexpected a particular network feature is. In this Review, Váša and Mišić describe different null-model approaches and instantiations, as well as their emerging uses and limitations.

    • František Váša
    • Bratislav Mišić
    Review Article
  • Hippocampal inhibitory interneurons shape memory formation and storage through cell type-specific mechanisms. In this review, Topolnik and Tamboli discuss how soma-targeting, dendrite-targeting and interneuron-targeting interneurons may specialize in supporting hippocampal oscillations, synaptic plasticity and memory processes.

    • Lisa Topolnik
    • Suhel Tamboli
    Review Article
  • Pathological forms of amyloid proteins, such as tau and α-synuclein, are thought to drive neurodegeneration. Li and Liu describe how techniques that reveal high-resolution protein structures can provide insight into polymorphic amyloid fibril formation and the relationships between amyloid protein conformation and disease.

    • Dan Li
    • Cong Liu
    Review Article
  • A population of spinal interneurons that express prokineticin receptor 2 is needed in mice for the rewarding, antistress and prosocial effects of pleasant touch.

    • Natasha Bray
    Research Highlight
  • Neuronal activity in a key region of the mouse hypothalamus modulates adult hippocampal neurogenesis, promoting the formation of adult-born neurons that support cognition and affective function.

    • Katherine Whalley
    Research Highlight
  • In rodents, absence seizures — a prominent manifestation of generalized epilepsy — drive activity-dependent myelination in the corpus callosum, increase interhemispheric synchrony and drive increases in seizure burden over time.

    • Sian Lewis
    Research Highlight
  • In this Review, Bradley, Nydam, Dux and Mattingley explore state-dependent variations in brain activity and behaviour with brain stimulation. They focus on transcranial magnetic stimulation and transcranial electrical stimulation and several domains — conscious state, attention and working memory.

    • Claire Bradley
    • Abbey S. Nydam
    • Jason B. Mattingley
    Review Article
  • Mice show degradation of their hippocampal place code when they disengage from a virtual goal-directed navigation task.

    • Darran Yates
    Research Highlight
  • Various theories have been developed for the biological and physical basis of consciousness. In this Review, Anil Seth and Tim Bayne discuss four prominent theoretical approaches to consciousness, namely higher-order theories, global workspace theories, re-entry and predictive processing theories and integrated information theory.

    • Anil K. Seth
    • Tim Bayne
    Review Article
  • Macroautophagy involves the delivery of various macromolecules and organelles to lysosomes for degradation. In this Review, Christopher Griffey and Ai Yamamoto provide an overview of this intracellular process and consider its modulation under physiological conditions and in brain disorders.

    • Christopher J. Griffey
    • Ai Yamamoto
    Review Article
  • The orbitofrontal cortex (OFC) has long been thought to track value, but new data implicate the OFC in the representation of cognitive maps of associative relationships. Here, Knudsen and Wallis review these hypotheses and examine how they might be reconciled.

    • Eric B. Knudsen
    • Joni D. Wallis
    Review Article
  • Food craving-like behaviours in pregnant mice are associated with changes in dopamine signalling.

    • Natasha Bray
    Research Highlight