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  • Recent advances in the development of gene therapy tools provide hope that these approaches might modulate the altered gene expression that characterizes many CNS disorders. Gao et al. provide an overview of current gene therapy strategies, highlighting the interdependence of therapeutic modality, delivery vehicle and administration route for translational success.

    • Jingjing Gao
    • Swetharajan Gunasekar
    • Nitin Joshi
    Review Article
  • Sabine Krabbe describes a 1993 study of classical conditioning in the honeybee that provided early insights into the mechanisms of predictive learning.

    • Sabine Krabbe
    Journal Club
  • In this Journal Club, Izumi Fukunaga discusses John Hopfield’s 1995 paper, which proposed a mechanism by which a continuously variable sensory stimulus can be transformed into a timing-based code.

    • Izumi Fukunaga
    Journal Club
  • The detection, discrimination and categorization of odours are essential for survival across the animal kingdom. In this Review, Datta and co-workers describe and compare the neural circuits that mediate the processing of olfactory information and the key principles of olfactory coding in insects and mammals.

    • Kara A. Fulton
    • David Zimmerman
    • Sandeep Robert Datta
    Review Article
  • Slowing neurodegeneration is the most pressing clinical need for multiple sclerosis (MS). In this Review, Woo, Engler and Friese provide a neuron-centric view on inflammation-induced neurodegeneration in MS and discuss key pathways and molecules that can be therapeutically targeted.

    • Marcel S. Woo
    • Jan Broder Engler
    • Manuel A. Friese
    Review Article
  • At early developmental stages, spontaneous activity in the mammalian cortex is characterized by the occurrence of highly synchronous network events. Portera-Cailliau and colleagues describe these activity patterns, their underlying mechanisms and function, and their transition to the desynchronized activity observed in adult individuals.

    • Michelle W. Wu
    • Nazim Kourdougli
    • Carlos Portera-Cailliau
    Review Article
  • A clinically viable speech neuroprosthesis could restore natural speech to individuals with vocal-tract paralysis. In this Review, Silva et al. discuss rapid progress in neural interfaces and computational algorithms for decoding speech from cortical activity and propose evaluation metrics to help standardize speech neuroprostheses.

    • Alexander B. Silva
    • Kaylo T. Littlejohn
    • Edward F. Chang
    Review Article
  • The location-specific firing of hippocampal place cells changes when an animal enters a new environment, a phenomenon known as ‘remapping’. In this Perspective, André A. Fenton challenges standard models of place cell remapping and proposes a key role for the ‘re-registration’ of internally organized place cell population dynamics in the encoding of distinct environments.

    • André A. Fenton
    Perspective
  • A subset of female mice that show anxiety-related traits seek out a starvation-like state when exposed to repeated stress

    • Katherine Whalley
    Research Highlight
  • The main direction of motor skill-specific information between rat primary motor cortex and dorsolateral striatum is shown to switch from cortex-predominant before learning to striatum-predominant after learning.

    • Sian Lewis
    Research Highlight
  • Many cognitive functions rely on the ability to link distinct but related memories, while retaining the capacity to recall the individual details of the linked memories. Inokuchi and colleagues describe evidence that memory linking involves engram overlap and discuss the mechanisms that regulate this process.

    • Ali Choucry
    • Masanori Nomoto
    • Kaoru Inokuchi
    Review Article